Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
about
Tcf7 is an important regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell lineRUNX1 truncation resulting from a cryptic and novel t(6;21)(q25;q22) chromosome translocation in acute myeloid leukemia: A case reportQuiescence of adult oligodendrocyte precursor cells requires thyroid hormone and hypoxia to activate Runx1.A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation.t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart developmentRunx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in miceIn vitro and in vivo effects on neural crest stem cell differentiation by conditional activation of Runx1 short isoform and its effect on neuropathic pain behavior.Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cellsPhosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice.Runx1 loss minimally impacts long-term hematopoietic stem cellsRunx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndromeCell cycle and developmental control of hematopoiesis by Runx1.RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesisRUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cellsA germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiationRUNX family: Regulation and diversification of roles through interacting proteins.RUNX1: A microRNA hub in normal and malignant hematopoiesis.A role for RUNX1 in hematopoiesis and myeloid leukemia.Runx1 Structure and Function in Blood Cell Development.RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress.Truncated RUNX1 protein generated by a novel t(1;21)(p32;q22) chromosomal translocation impairs the proliferation and differentiation of human hematopoietic progenitors.Identification of a novel fusion gene involving RUNX1 and the antisense strand of SV2B in a BCR-ABL1-positive acute leukemia.Response: the role of RUNX1 isoforms in hematopoietic commitment of human pluripotent stem cells.Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis.LincRNA-uc002yug.2 involves in alternative splicing of RUNX1 and serves as a predictor for esophageal cancer and prognosis.
P2860
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P2860
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
@ast
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
@en
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
@nl
type
label
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
@ast
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
@en
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
@nl
prefLabel
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
@ast
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
@en
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
@nl
P2093
P2860
P3181
P1433
P1476
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
@en
P2093
Dengli Hong
Masao Seto
Rajeev Gupta
Shinobu Tsuzuki
P2860
P3181
P356
10.1371/JOURNAL.PMED.0040172
P407
P577
2007-05-01T00:00:00Z