The architecture of the spliceosomal U4/U6.U5 tri-snRNP.
about
The nuts and bolts of the endogenous spliceosomeThe organization and contribution of helicases to RNA splicingCryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feastStructural basis of complement membrane attack complex formation.Structure of a yeast spliceosome at 3.6-angstrom resolutionThe 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysisTranscription initiation complex structures elucidate DNA openingCryo-EM structure of the spliceosome immediately after branchingPrp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.Structural and mechanistic insights into human splicing factor SF3b complex derived using an integrated approach guided by the cryo-EM density mapsResolution advances in cryo-EM enable application to drug discovery.Structure of a group II intron in complex with its reverse transcriptaseCryo-EM study of start codon selection during archaeal translation initiationFgPrp4 Kinase Is Important for Spliceosome B-Complex Activation and Splicing Efficiency in Fusarium graminearum.Structural studies of the endogenous spliceosome - The supraspliceosome.A local-optimization refinement algorithm in single particle analysis for macromolecular complex with multiple rigid modulesSampling the conformational space of the catalytic subunit of human γ-secretaseTwo promising future developments of cryo-EM: capturing short-lived states and mapping a continuum of states of a macromoleculeStructural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly.Structural Analysis of Multi-Helical RNAs by NMR-SAXS/WAXS: Application to the U4/U6 di-snRNA.Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolutionRetinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase ActivityStructure-function analysis and genetic interactions of the SmG, SmE, and SmF subunits of the yeast Sm protein ring.Single-Particle Refinement and Variability Analysis in EMAN2.1.Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulationThe power of fission: yeast as a tool for understanding complex splicing.RNA and Proteins: Mutual Respect.Re-refinement of the spliceosomal U4 snRNP core-domain structure.Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution.Single-particle cryo-electron microscopy of macromolecular complexes.Methodologies for studying the spliceosome's RNA dynamics with single-molecule FRET.Lights, camera, action! Capturing the spliceosome and pre-mRNA splicing with single-molecule fluorescence microscopy.RNA structure through multidimensional chemical mapping.Therapeutic targeting of splicing in cancer.Cajal bodies and snRNPs - friends with benefits.While the revolution will not be crystallized, biochemistry reigns supreme.Functions and regulation of the Brr2 RNA helicase during splicing.Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core.Genetics and biochemistry remain essential in the structural era of the spliceosome.Structural Insights into the Mechanism of Group II Intron Splicing.
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P2860
The architecture of the spliceosomal U4/U6.U5 tri-snRNP.
description
2015 nî lūn-bûn
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2015 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
name
The architecture of the spliceosomal U4/U6.U5 tri-snRNP
@nl
The architecture of the spliceosomal U4/U6.U5 tri-snRNP.
@ast
The architecture of the spliceosomal U4/U6.U5 tri-snRNP.
@en
type
label
The architecture of the spliceosomal U4/U6.U5 tri-snRNP
@nl
The architecture of the spliceosomal U4/U6.U5 tri-snRNP.
@ast
The architecture of the spliceosomal U4/U6.U5 tri-snRNP.
@en
prefLabel
The architecture of the spliceosomal U4/U6.U5 tri-snRNP
@nl
The architecture of the spliceosomal U4/U6.U5 tri-snRNP.
@ast
The architecture of the spliceosomal U4/U6.U5 tri-snRNP.
@en
P2093
P2860
P50
P3181
P356
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P1476
The architecture of the spliceosomal U4/U6.U5 tri-snRNP
@en
P2093
Andrew J Newman
Christos G Savva
Kiyoshi Nagai
Thi Hoang Duong Nguyen
P2860
P2888
P3181
P356
10.1038/NATURE14548
P407
P577
2015-06-24T00:00:00Z
P6179
1040399474