PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
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Membrane Binding and Modulation of the PDZ Domain of PICK1The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core VesiclesPICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose toleranceInsulin/IGF-regulated size scaling of neuroendocrine cells expressing the bHLH transcription factor Dimmed in DrosophilaSyntabulin regulates the trafficking of PICK1-containing vesicles in neurons.Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.PICK1 is implicated in organelle motility in an Arp2/3 complex-independent mannerMyosin 1b and F-actin are involved in the control of secretory granule biogenesisSORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells.Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED.Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering.Compromised central tolerance of ICA69 induces multiple organ autoimmunity.New loci for body fat percentage reveal link between adiposity and cardiometabolic disease riskDifferential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini.Factors that regulate insulin producing cells and their output in Drosophila.Rescuing infertility of Pick1 knockout mice by generating testis-specific transgenic mice via testicular infectionHID-1 is required for homotypic fusion of immature secretory granules during maturation.The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells.The SNARE protein vti1a functions in dense-core vesicle biogenesisPICK1 is Essential for Insulin Production and the Maintenance of Glucose Homeostasis.HID-1 controls formation of large dense core vesicles by influencing cargo sorting and trans-Golgi network acidification.The dense-core vesicle maturation protein CCCP-1 binds RAB-2 and membranes through its C-terminal domain.Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity.Evidence of genetic predisposition for metabolically healthy obesity and metabolically obese normal weight.Neuroendocrinology: regulated secretory cells go to the BAR for a bud.Control of Insulin Granule Formation and Function by the ABC Transporters ABCG1 and ABCA1 and by Oxysterol Binding Protein OSBP.Prolactin selectively transported to cerebrospinal fluid from blood under hypoxic/ischemic conditions.Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells
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P2860
PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
description
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
article scientifique (publié 2013)
@fr
articolo scientifico (pubblicato il 2013)
@it
artigo científico (publicado na 2013)
@pt
artículu científicu espublizáu en 2013
@ast
im Januar 2013 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 2013)
@en
vedecký článok (publikovaný 2013)
@sk
videnskabelig artikel (udgivet 2013)
@da
name
PICK1 deficiency impairs secre ...... nd decreased glucose tolerance
@ast
PICK1 deficiency impairs secre ...... nd decreased glucose tolerance
@en
PICK1 deficiency impairs secre ...... nd decreased glucose tolerance
@nl
type
label
PICK1 deficiency impairs secre ...... nd decreased glucose tolerance
@ast
PICK1 deficiency impairs secre ...... nd decreased glucose tolerance
@en
PICK1 deficiency impairs secre ...... nd decreased glucose tolerance
@nl
prefLabel
PICK1 deficiency impairs secre ...... nd decreased glucose tolerance
@ast
PICK1 deficiency impairs secre ...... nd decreased glucose tolerance
@en
PICK1 deficiency impairs secre ...... nd decreased glucose tolerance
@nl
P2093
P2860
P50
P3181
P1433
P1476
PICK1 deficiency impairs secre ...... nd decreased glucose tolerance
@en
P2093
Andreas N Madsen
Anna M Jansen
Chunyu Jin
Gunnar Sørensen
Kenneth L Madsen
Mattias Rickhag
Morten Jensen
Ole Kjærulff
Richard Huganir
Siri K Møller
P2860
P304
P3181
P356
10.1371/JOURNAL.PBIO.1001542
P407
P577
2013-01-01T00:00:00Z