about
Ghrelin receptor mutations--too little height and too much hunger.PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose toleranceGhrelin.High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonistCharacterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involvedGPR39 signaling is stimulated by zinc ions but not by obestatinCommon structural basis for constitutive activity of the ghrelin receptor familyA library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled ...GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissueDeficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolismG protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunctionOverlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity.Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation.MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 EuropeansSafety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover studyAllosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivoMolecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe.GPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampusDietary non-esterified oleic Acid decreases the jejunal levels of anorectic N-acylethanolamines.Physiological and pathological impact of blood sampling by retro-bulbar sinus puncture and facial vein phlebotomy in laboratory mice.Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation.Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism.Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions.Molecular mechanism of 7TM receptor activation--a global toggle switch model.Acylation type determines ghrelin's effects on energy homeostasis in rodents.Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors.FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the LiverC4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes.Anxiolytic-Like Effects of Increased Ghrelin Receptor Signaling in the Amygdala.Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor.Ligand binding and micro-switches in 7TM receptor structures.GPR39 Zn(2+)-sensing receptor: a new target in antidepressant development?Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area.Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo.Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery.Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice.β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced HyperglycemiaMolecular basis for agonism in the BB3 receptor: an epitope located on the interface of transmembrane-III, -VI, and -VII.
P50
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P50
description
hulumtuese
@sq
onderzoeker
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researcher
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հետազոտող
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name
B Holst
@ast
B Holst
@nl
Birgitte Holst
@en
Birgitte Holst
@es
type
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B Holst
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B Holst
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Birgitte Holst
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Birgitte Holst
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B Holst
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Holst B
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B Holst
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B Holst
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Birgitte Holst
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Birgitte Holst
@es
P106
P21
P31
P496
0000-0001-7432-097X