In vitro selection of mutant HDM2 resistant to Nutlin inhibition - Wikidata - wikimedia - TriplyDB

In vitro selection of mutant HDM2 resistant to Nutlin inhibition

In vitro selection of mutant HDM2 resistant to Nutlin inhibition

http://www.wikidata.org/entity/Q27322456

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Inhibition of nutlin-resistant HDM2 mutants by stapled peptides Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction The p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens Avoiding drug resistance through extended drug target interfaces: a case for stapled peptides Pre-clinical efficacy and synergistic potential of the MDM2-p53 antagonists, Nutlin-3 and RG7388, as single agents and in combined treatment with cisplatin in ovarian cancer.The clinical development of p53-reactivating drugs in sarcomas - charting future therapeutic approaches and understanding the clinical molecular toxicology of Nutlins.Resistance acquisition to MDM2 inhibitors.Pharmacological activation of wild-type p53 in the therapy of leukemia.Peptides and peptidomimetics in the p53/MDM2/MDM4 circuitry - a patent review.A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein-protein interactions identifies a novel putative Mdm2-binding site in p53.

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In vitro selection of mutant HDM2 resistant to Nutlin inhibition

http://www.wikidata.org/entity/Q27322456

description

2013 nî lūn-bûn

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2013 թուականին հրատարակուած գիտական յօդուած

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2013 թվականին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

In vitro selection of mutant HDM2 resistant to Nutlin inhibition

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In vitro selection of mutant HDM2 resistant to Nutlin inhibition

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In vitro selection of mutant HDM2 resistant to Nutlin inhibition

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type

label

In vitro selection of mutant HDM2 resistant to Nutlin inhibition

@ast

In vitro selection of mutant HDM2 resistant to Nutlin inhibition

@en

In vitro selection of mutant HDM2 resistant to Nutlin inhibition

@nl

prefLabel

In vitro selection of mutant HDM2 resistant to Nutlin inhibition

@ast

In vitro selection of mutant HDM2 resistant to Nutlin inhibition

@en

In vitro selection of mutant HDM2 resistant to Nutlin inhibition

@nl

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In vitro selection of mutant HDM2 resistant to Nutlin inhibition

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Adelene Y L Sim

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Chandra Verma

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Kourosh Zolghadr

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Larisa Yurlova

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Siau Jia Wei

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Thomas Joseph

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P2860

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

Mdm2 promotes the rapid degradation of p53

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

D-peptide inhibitors of the p53–MDM2 interaction for targeted molecular therapy of malignant neoplasms

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Farid J Ghadessy

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