Adult onset global loss of the fto gene alters body composition and metabolism in the mouse - Wikidata - wikimedia - TriplyDB

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

http://www.wikidata.org/entity/Q27325807

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Conceptual heuristic models of the interrelationships between obesity and the occupational environment The bigger picture of FTO: the first GWAS-identified obesity gene Role of FTO in Adipocyte Development and Function: Recent Insights Obesity genetics in mouse and human: back and forth, and back again Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies Obesity-associated variants within FTO form long-range functional connections with IRX3 FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals.Age- and sex-dependent association between FTO rs9939609 and obesity-related traits in Chinese children and adolescents.Changes in gene expression associated with FTO overexpression in mice.The pathogenesis of obesity from a genomic and systems biology perspective.Complex Relationship between Obesity and the Fat Mass and Obesity Locus FTO is a relevant factor for the development of the metabolic syndrome in mice.Fat mass and obesity-associated (FTO) gene polymorphisms are associated with physical activity, food intake, eating behaviors, psychological health, and modeled change in body mass index in overweight/obese Caucasian adults A link between FTO, ghrelin, and impaired brain food-cue responsivity.The biology of FTO: from nucleic acid demethylase to amino acid sensor.FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.FTO influences adipogenesis by regulating mitotic clonal expansion The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation.N6-methyladenosine modification in mRNA: machinery, function and implications for health and diseases.Emerging function of fat mass and obesity-associated protein (fto)FTO knockdown in rat ventromedial hypothalamus does not affect energy balance Signs of cardiac autonomic imbalance and proarrhythmic remodeling in FTO deficient mice Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue Pharmacological inhibition of FTO.Associations between FTO genotype and total energy and macronutrient intake in adults: a systematic review and meta-analysis.Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy.Hypomorphism of Fto and Rpgrip1l causes obesity in mice.Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents.Fto-Deficiency Affects the Gene and MicroRNA Expression Involved in Brown Adipogenesis and Browning of White Adipose Tissue in Mice.FTO is required for myogenesis by positively regulating mTOR-PGC-1α pathway-mediated mitochondria biogenesis.Mapping and significance of the mRNA methylome.Programming effects of FTO in the development of obesity.FTO and obesity: mechanisms of association.Genetic strategies to understand physiological pathways regulating body weight.FTO is necessary for the induction of leptin resistance by high-fat feeding.Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.The 'Fat Mass and Obesity Related' (FTO) gene: Mechanisms of Impact on Obesity and Energy Balance.Comprehensive Energy Balance Measurements in Mice.Is genetic testing of value in predicting and treating obesity?Loss of FTO in adipose tissue decreases Angptl4 translation and alters triglyceride metabolism.

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Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

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Adult onset global loss of the ...... on and metabolism in the mouse

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Chris D Church

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Debra Rimmington

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George Nicholson

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Lydia Teboul

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Y C Loraine Tung

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P2860

N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

Crystal structure of the FTO protein reveals basis for its substrate specificity

Hypothalamic FTO is associated with the regulation of energy intake not feeding reward

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

Inactivation of the Fto gene protects from obesity

The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain

Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure

Obesity associated genetic variation in FTO is associated with diminished satiety

The FTO gene and measured food intake in children

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10.1371/JOURNAL.PGEN.1003166

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Giles See How Yeo

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