about
Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancerAdult onset global loss of the fto gene alters body composition and metabolism in the mouseCNS-directed gene therapy for the treatment of neurologic and somatic mucopolysaccharidosis type II (Hunter syndrome)Vanadate treatment restores the expression of genes for key enzymes in the glucose and ketone bodies metabolism in the liver of diabetic ratsCDK4 is an essential insulin effector in adipocytesPhosphofructo-1-kinase deficiency leads to a severe cardiac and hematological disorder in addition to skeletal muscle glycogenosisTreatment of diabetes and long-term survival after insulin and glucokinase gene therapy.Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapyHypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.Contribution of Intronic miR-338-3p and Its Hosting Gene AATK to Compensatory β-Cell Mass Expansion.AAV-mediated pancreatic overexpression of Igf1 counteracts progression to autoimmune diabetes in mice.Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.Characterization of a recombinant adeno-associated virus type 2 Reference Standard MaterialManufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material.Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only miceTransgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells.Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression.LRH-1-dependent glucose sensing determines intermediary metabolism in liver.Proinsulin slows retinal degeneration and vision loss in the P23H rat model of retinitis pigmentosamTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue.Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction.Insulin-like growth factor I (IGF-I)-induced chronic gliosis and retinal stress lead to neurodegeneration in a mouse model of retinopathyEnforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain.Progressive neurologic and somatic disease in a novel mouse model of human mucopolysaccharidosis type IIIC.Correction of diabetic alterations by glucokinase.Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver diseaseSkeletal muscle metabolism in the pathology and treatment of type 1 diabetes.Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistancePrevention of diabetic alterations in transgenic mice overexpressing Myc in the liver.Production, purification and characterization of adeno-associated vectors.Proliferative retinopathies: animal models and therapeutic opportunities.Relevance of an academic GMP Pan-European vector infra-structure (PEVI).ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage.AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistanceIn vivo adeno-associated viral vector-mediated genetic engineering of white and brown adipose tissue in adult mice.Beta cell expression of IGF-I leads to recovery from type 1 diabetes.Disease correction by AAV-mediated gene therapy in a new mouse model of mucopolysaccharidosis type IIID.Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
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name
Fatima Bosch
@ast
Fatima Bosch
@en
Fatima Bosch
@es
Fatima Bosch
@nl
type
label
Fatima Bosch
@ast
Fatima Bosch
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Fatima Bosch
@es
Fatima Bosch
@nl
altLabel
FATIMA BOSCH
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prefLabel
Fatima Bosch
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Fatima Bosch
@en
Fatima Bosch
@es
Fatima Bosch
@nl
P108
P214
P106
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P1153
7201833372
P1580
P214
P31
P496
0000-0002-7705-5515
P734
P7859
viaf-305864250