Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs
about
Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.Anti-proliferative and pro-apoptotic effects of cinobufagin on human breast cancer MCF-7 cells and its molecular mechanism.Gypenosides suppress growth of human oral cancer SAS cells in vitro and in a murine xenograft model: the role of apoptosis mediated by caspase-dependent and caspase-independent pathways.Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis.Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation.Management of cytoskeleton architecture by molecular chaperones and immunophilins.Scrophularia orientalis extract induces calcium signaling and apoptosis in neuroblastoma cells.Celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targetsImbalance of Hsp70 family variants fosters tau accumulation.FBS or BSA Inhibits EGCG Induced Cell Death through Covalent Binding and the Reduction of Intracellular ROS Production.Natural friedelanes.Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products.Cytotoxic effect of celastrol alone or in combination with paclitaxel on anaplastic thyroid carcinoma cells.Cabazitaxel for the treatment of castration-resistant prostate cancer.The extent of neurodegeneration and neuroprotection in two chemical in vitro models related to Parkinson's disease is critically dependent on cell culture conditions.Compounds From Celastraceae Targeting Cancer Pathways and Their Potential Application in Head and Neck Squamous Cell Carcinoma: A Review.Acquiring Metastatic Competence by Oral Squamous Cell Carcinoma Cells Is Associated with Differential Expression of α-Tubulin Isoforms.Gold nanourchins and celastrol reorganize the nucleo- and cytoskeleton of glioblastoma cells.
P2860
Q30499793-DDD34137-2CEA-4AC5-95E9-CEA99FD87E4BQ32178306-97D34863-F993-4A77-8D6C-B27FD37627B5Q33930229-850AAAD0-8BB5-4C29-A0E1-D9D0889EDCF4Q34482963-D214A532-DCFB-4C02-94FD-5EF3AED8EE34Q35213267-774165D4-8C6B-41B4-835A-EF41842E8960Q35250454-4E36A46D-FBA2-4917-A61D-3F30E26D29E9Q35915247-E049B4F5-B575-4EBB-82D6-137246977D0BQ35973531-F153715C-396C-4206-91F9-BCB105DE6097Q36710912-227E46AB-B490-40FB-AC2B-3AC73D50F8A8Q37382676-41226CFD-72C2-4990-BEE2-D88CE7C83287Q38128529-B6B0DA6B-CD1A-41DF-B6E5-34720F70D70DQ38510631-6EDC4A2A-444E-467F-A2B3-B2C6B1FED855Q38705383-3224BE40-9A12-41D2-AF81-C65BF2401559Q38861952-E4D98471-C4C7-4065-AE3C-B63CB017C643Q39212503-8D797AE3-5A63-4C0F-B0A3-7559FA74C6E2Q39305660-BEECBC6C-1291-49C2-86A5-A76B71543EA3Q41844229-357A1452-777C-4DAC-868B-576DC38514A3Q47225712-393EEB5C-00FB-4995-A0EE-1F50AB3492AA
P2860
Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs
description
2010 nî lūn-bûn
@nan
2010 թուականին հրատարակուած գիտական յօդուած
@hyw
2010 թվականին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Natural product Celastrol dest ...... le-targeting anti-cancer drugs
@ast
Natural product Celastrol dest ...... le-targeting anti-cancer drugs
@en
Natural product Celastrol dest ...... le-targeting anti-cancer drugs
@nl
type
label
Natural product Celastrol dest ...... le-targeting anti-cancer drugs
@ast
Natural product Celastrol dest ...... le-targeting anti-cancer drugs
@en
Natural product Celastrol dest ...... le-targeting anti-cancer drugs
@nl
prefLabel
Natural product Celastrol dest ...... le-targeting anti-cancer drugs
@ast
Natural product Celastrol dest ...... le-targeting anti-cancer drugs
@en
Natural product Celastrol dest ...... le-targeting anti-cancer drugs
@nl
P2093
P2860
P3181
P1433
P1476
Natural product Celastrol dest ...... le-targeting anti-cancer drugs
@en
P2093
Fabien Loison
Hakryul Jo
Hidenori Hattori
Hongbo R Luo
Hongtao Yu
Leslie E Silberstein
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0010318
P407
P577
2010-01-01T00:00:00Z