Imbalance of Hsp70 family variants fosters tau accumulation.
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Hsp90-Tau complex reveals molecular basis for specificity in chaperone actionNMR Meets Tau: Insights into Its Function and PathologyThe Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a CostPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Tau-tubulin kinaseHydrogel-based nanocomposites and mesenchymal stem cells: a promising synergistic strategy for neurodegenerative disorders therapyBiochemical and Proteomic Analysis of Ubiquitination of Hsc70 and Hsp70 by the E3 Ligase CHIPHeat shock protein 70 in Alzheimer's diseaseC-terminal amino acids are essential for human heat shock protein 70 dimerizationInducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22.Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance.Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease.Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone ComplementPrion-Associated Toxicity is Rescued by Elimination of Cotranslational Chaperones.Targeting protein aggregation for the treatment of degenerative diseasesIdentification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain.A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases.Potential synergy between tau aggregation inhibitors and tau chaperone modulators.Hsp70 in cancer: back to the future.Cellular factors modulating the mechanism of tau protein aggregation.Extracellular Tau Paired Helical Filaments Differentially Affect Tau Pathogenic Mechanisms in Mitotic and Post-Mitotic Cells: Implications for Mechanisms of Tau Propagation in the Brain.DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins.Targeting the Diabetic Chaperome to Improve Peripheral Neuropathy.Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.Therapeutic Strategies for Restoring Tau Homeostasis.Designer protein disaggregases to counter neurodegenerative disease.The remarkable multivalency of the Hsp70 chaperones.Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1.Backbone and methyl resonance assignments of the 42 kDa human Hsc70 nucleotide binding domain in the ADP state.Non-canonical Interactions between Heat Shock Cognate Protein 70 (Hsc70) and Bcl2-associated Anthanogene (BAG) Co-Chaperones Are Important for Client Release.Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of TauopathySpecific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.Identification of a Large DNAJB2 Deletion in a Family with Spinal Muscular Atrophy and Parkinsonism.HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation.Enhanced tau pathology via RanBP9 and Hsp90/Hsc70 chaperone complexes.Adapting to stress - chaperome networks in cancer.Mapping interactions with the chaperone network reveals factors that protect against tau aggregationTargeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD
P2860
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P2860
Imbalance of Hsp70 family variants fosters tau accumulation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Imbalance of Hsp70 family variants fosters tau accumulation.
@ast
Imbalance of Hsp70 family variants fosters tau accumulation.
@en
type
label
Imbalance of Hsp70 family variants fosters tau accumulation.
@ast
Imbalance of Hsp70 family variants fosters tau accumulation.
@en
prefLabel
Imbalance of Hsp70 family variants fosters tau accumulation.
@ast
Imbalance of Hsp70 family variants fosters tau accumulation.
@en
P2093
P2860
P50
P356
P1433
P1476
Imbalance of Hsp70 family variants fosters tau accumulation.
@en
P2093
Andrea D Thompson
Bryce A Nordhues
Chad A Dickey
Elias Akoury
Jacek Biernat
Jason E Gestwicki
John C O'Leary
Jose F Abisambra
Juan Zhang
P2860
P304
P356
10.1096/FJ.12-220889
P407
P577
2012-12-27T00:00:00Z