Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease - Wikidata - wikimedia - TriplyDB

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

http://www.wikidata.org/entity/Q27349980

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Zinc diet and Alzheimer's disease: a systematic review Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis Issues raised involving the copper hypotheses in the causation of Alzheimer's disease Disturbed copper bioavailability in Alzheimer's disease 8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications Copper chelator induced efficient episodic memory recovery in a non-transgenic Alzheimer's mouse model Spectral analysis of naturally occurring methylxanthines (theophylline, theobromine and caffeine) binding with DNA Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's Disease The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease Metal chaperones: a holistic approach to the treatment of Alzheimer's disease Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory.Spatial memory deficits in a mouse model of late-onset Alzheimer's disease are caused by zinc supplementation and correlate with amyloid-beta levels A single administration of human umbilical cord blood T cells produces long-lasting effects in the aging hippocampus Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.Modifications of hippocampal circuits and early disruption of adult neurogenesis in the tg2576 mouse model of Alzheimer's disease.A novel approach to rapidly prevent age-related cognitive decline Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.Copper modulation as a therapy for Alzheimer's disease?The neurophysiology and pathology of brain zinc.New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.Metal attenuating therapies in neurodegenerative disease.Role of APP for dendritic spine formation and stability.Copper complexes as therapeutic agents.Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer's disease.Metallostasis and amyloid β-degrading enzymes.Metallobiology of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.What can flies tell us about copper homeostasis?Biological metals and metal-targeting compounds in major neurodegenerative diseases.β-Amyloid peptides and amyloid plaques in Alzheimer's disease.Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer's Disease: What are the Roadblocks and How Can They Be Overcome?Behind the curtain of tauopathy: a show of multiple players orchestrating tau toxicity.Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics.Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: mechanistic insights and design rules.Copper, differently from zinc, affects the conformation, oligomerization state and activity of bradykinin.Protection from neurodegeneration in the 6-hydroxydopamine (6-OHDA) model of Parkinson's with novel 1-hydroxypyridin-2-one metal chelators.Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives.Subcellular localization of a fluorescent derivative of CuII(atsm) offers insight into the neuroprotective action of CuII(atsm).The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity.An N-heterocyclic amine chelate capable of antioxidant capacity and amyloid disaggregation.

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Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

http://www.wikidata.org/entity/Q27349980

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Metal ionophore treatment rest ...... e model of Alzheimer's disease

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Metal ionophore treatment rest ...... e model of Alzheimer's disease

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David I Finkelstein

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Gulay Filiz

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Laura Bica

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Milawaty Nurjono

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Paul A Adlard

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Paul S Donnelly

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P2860

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

The molecular basis of CaMKII function in synaptic and behavioural memory

Structural basis of long-term potentiation in single dendritic spines

Dendritic spine changes associated with hippocampal long-term synaptic plasticity

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity

Spatial relationship between synapse loss and beta-amyloid deposition in Tg2576 mice.

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease.

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.

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Anthony R. White

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Alzheimer's disease

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3055881

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