about
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's diseaseNeuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.Metals and amyloid-beta in Alzheimer's diseaseMetal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's diseaseCrystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor proteinStructure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasisStructural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ionsStructure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolutionAmyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitopeQuantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological functionIdentification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growthCopper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout miceGene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblastsNeurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways.Dimeric structures of alpha-synuclein bind preferentially to lipid membranes.Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation.A serial analysis of gene expression profile of the Alzheimer's disease Tg2576 mouse model.The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.Amyloid beta.Conservation of a glycine-rich region in the prion protein is required for uptake of prion infectivityAmyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfateCopper binding to the Alzheimer's disease amyloid precursor proteinAmyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina.Alois Alzheimer and Alzheimer's disease: a centennial perspective.Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease.Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the aggregating species.Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.The N-terminal residues 43 to 60 form the interface for dopamine mediated α-synuclein dimerisation.Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation.The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's diseaseThe amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism.Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Abeta peptides associated with Alzheimer's disease.Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's diseaseThe redox chemistry of the Alzheimer's disease amyloid beta peptide.Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation.The interplay between lipids and dopamine on α-synuclein oligomerization and membrane binding.Modulation of alpha-synuclein aggregation by dopamine: a review.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Roberto Cappai
@ast
Roberto Cappai
@en
Roberto Cappai
@es
Roberto Cappai
@nl
Roberto Cappai
@sl
type
label
Roberto Cappai
@ast
Roberto Cappai
@en
Roberto Cappai
@es
Roberto Cappai
@nl
Roberto Cappai
@sl
prefLabel
Roberto Cappai
@ast
Roberto Cappai
@en
Roberto Cappai
@es
Roberto Cappai
@nl
Roberto Cappai
@sl
P1053
B-3347-2010
P106
P1153
35428820500
P21
P31
P3829
P496
0000-0002-9505-8496