Structure-based discovery of dengue virus protease inhibitors - Wikidata - wikimedia - TriplyDB

Structure-based discovery of dengue virus protease inhibitors

Structure-based discovery of dengue virus protease inhibitors

http://www.wikidata.org/entity/Q27488378

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Human heme oxygenase 1 is a potential host cell factor against dengue virus replication Serotype-Specific Structural Differences in the Protease-Cofactor Complexes of the Dengue Virus Family High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease.A novel transport mechanism for MOMP in Chlamydophila pneumoniae and its putative role in immune-therapy Transplantation of a hydrogen bonding network from West Nile virus protease onto Dengue-2 protease improves catalytic efficiency and sheds light on substrate specificity.New binding site conformations of the dengue virus NS3 protease accessed by molecular dynamics simulation.Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B-NS3 proteinase of West Nile virus.High-content assay to identify inhibitors of dengue virus infection Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase.Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus.Recombinant expression and functional analysis of proteases from Streptococcus pneumoniae, Bacillus anthracis, and Yersinia pestis.Using free energy of binding calculations to improve the accuracy of virtual screening predictions.Use of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors.A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro Anthracene-based inhibitors of dengue virus NS2B-NS3 protease The flavivirus protease as a target for drug discovery.Small molecule pan-dengue and West Nile virus NS3 protease inhibitors.A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease Identification of dengue viral RNA-dependent RNA polymerase inhibitor using computational fragment-based approaches and molecular dynamics study.Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells.Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase Rational identification of enoxacin as a novel V-ATPase-directed osteoclast inhibitor.Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases Rational prediction with molecular dynamics for hit identification Targeting host factors to treat West Nile and dengue viral infections.Drugs for dengue: a patent review (2010-2014).Structural and functional parameters of the flaviviral protease: a promising antiviral drug target.Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities.3D-QSAR pharmacophore-based virtual screening, molecular docking and molecular dynamics simulation toward identifying lead compounds for NS2B-NS3 protease inhibitors.Varying structural motifs in the salen based metal complexes of Co(ii), Ni(ii) and Cu(ii): synthesis, crystal structures, molecular dynamics and biological activities.Ethyl 4-(4-methylphenyl)-4-pentenoate from Vetiveria zizanioides Inhibits Dengue NS2B-NS3 Protease and Prevents Viral Assembly: A Computational Molecular Dynamics and Docking Study.Structure-guided fragment-based in silico drug design of dengue protease inhibitors.Binding mode of the activity-modulating C-terminal segment of NS2B to NS3 in the dengue virus NS2B-NS3 protease.Structure-guided Discovery of a Novel Non-peptide Inhibitor of Dengue Virus NS2B-NS3 Protease.Pharmacophore anchor models of flaviviral NS3 proteases lead to drug repurposing for DENV infection.Targeting intramolecular proteinase NS2B/3 cleavages for -dominant inhibition of dengue virus

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P2860

Structure-based discovery of dengue virus protease inhibitors

http://www.wikidata.org/entity/Q27488378

description

2009 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հունիսին հրատարակված գիտական հոդված

@hy

article scientifique (publié 2009-06)

@fr

articolo scientifico (pubblicato il 2009-06)

@it

artigo científico (publicado na 2009-06)

@pt

artículu científicu espublizáu en 2009

@ast

im Juni 2009 veröffentlichter wissenschaftlicher Artikel

@de

scientific article (publication date: June 2009)

@en

vedecký článok (publikovaný 2009-06)

@sk

videnskabelig artikel (udgivet 2009-06)

@da

name

Structure-based discovery of dengue virus protease inhibitors

@ast

Structure-based discovery of dengue virus protease inhibitors

@en

Structure-based discovery of dengue virus protease inhibitors

@nl

type

label

Structure-based discovery of dengue virus protease inhibitors

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Structure-based discovery of dengue virus protease inhibitors

@en

Structure-based discovery of dengue virus protease inhibitors

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prefLabel

Structure-based discovery of dengue virus protease inhibitors

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Structure-based discovery of dengue virus protease inhibitors

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Structure-based discovery of dengue virus protease inhibitors

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J.ANTIVIRAL.2009.02.190

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Antiviral Research

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Structure-based discovery of dengue virus protease inhibitors

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Andrew Russo

http://www.w3.org/2001/XMLSchema#string

Niklaus Mueller

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Robert D Malmstrom

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Stanley J Watowich

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Suzanne M Tomlinson

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Yuan-Ping Pang

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Molecular targets for flavivirus drug discovery

Observations related to the pathogenesis of dengue hemorrhagic fever. II. Antigenic and biologic properties of dengue viruses and their association with disease response in the host

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

Accurate reproduction of 161 small-molecule complex crystal structures using the EUDOC program: expanding the use of EUDOC to supramolecular chemistry

Neutralization and antibody-dependent enhancement of dengue viruses

Research on dengue during World War II

Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein

Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses

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