Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein
about
Molecular targets for flavivirus drug discoveryStructure and functionality in flavivirus NS-proteins: perspectives for drug designEvolutionary families of peptidasesKinetic and structural analyses of hepatitis C virus polyprotein processingFlaviviral Replication Complex: Coordination between RNA Synthesis and 5'-RNA CappingRecombinant yellow fever viruses are effective therapeutic vaccines for treatment of murine experimental solid tumors and pulmonary metastases.The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acidsMutagenesis of the NS3 protease of dengue virus type 2.Characterization of defective viral RNA produced during persistent infection of Vero cells with Murray Valley encephalitis virusHepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivoSubcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines.Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function.Mutagenesis of the NS2B-NS3-mediated cleavage site in the flavivirus capsid protein demonstrates a requirement for coordinated processingIsolation and characterization of noncytopathic pestivirus mutants reveals a role for nonstructural protein NS4B in viral cytopathogenicity.Attenuation of Murray Valley encephalitis virus by site-directed mutagenesis of the hinge and putative receptor-binding regions of the envelope protein.Complementation analysis of the flavivirus Kunjin NS3 and NS5 proteins defines the minimal regions essential for formation of a replication complex and shows a requirement of NS3 in cis for virus assembly.Sequence comparison and secondary structure analysis of the 3' noncoding region of flavivirus genomes reveals multiple pseudoknots.Langat Flavivirus Protease NS3 Binds Caspase-8 and Induces ApoptosisProbing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptidesTranslation of the Flavivirus Kunjin NS3 Gene in cis but Not Its RNA Sequence or Secondary Structure Is Essential for Efficient RNA PackagingDe Novo Synthesis of Negative-Strand RNA by Dengue Virus RNA-Dependent RNA Polymerase In Vitro: Nucleotide, Primer, and Template ParametersCuration of viral genomes: challenges, applications and the way forwardMutagenesis of the yellow fever virus NS2B/3 cleavage site: determinants of cleavage site specificity and effects on polyprotein processing and viral replicationFormation of the flavivirus envelope: role of the viral NS2B-NS3 proteaseNS3-4A of hepatitis C virus is a chymotrypsin-like proteaseHepatitis C virus-encoded NS2-3 protease: cleavage-site mutagenesis and requirements for bimolecular cleavageA central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitroPosttranslational signal peptidase cleavage at the flavivirus C-prM junction in vitroEnzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon systemGenetic analysis of the yellow fever virus NS1 protein: identification of a temperature-sensitive mutation which blocks RNA accumulationUpregulation of signalase processing and induction of prM-E secretion by the flavivirus NS2B-NS3 protease: roles of protease componentsBovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replicationProbing the substrate specificity of hepatitis C virus NS3 serine protease by using synthetic peptidesCharacterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoiresCross-Reactive T-Cell Responses to the Nonstructural Regions of Dengue Viruses among Dengue Fever and Dengue Hemorrhagic Fever Patients in MalaysiaConstruction and characterization of recombinant flaviviruses bearing insertions between E and NS1 genesStructural evidence for regulation and specificity of flaviviral proteases and evolution of theFlaviviridaefoldFunctional Analysis of Potential Carboxy-Terminal Cleavage Sites of Tick-Borne Encephalitis Virus Capsid ProteinYellow Fever Virus NS3 Plays an Essential Role in Virus Assembly Independent of Its Known Enzymatic FunctionsCompletion of Kunjin virus RNA sequence and recovery of an infectious RNA transcribed from stably cloned full-length cDNA
P2860
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P2860
Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein
description
1990 nî lūn-bûn
@nan
1990 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Evidence that the N-terminal d ...... vages in the viral polyprotein
@ast
Evidence that the N-terminal d ...... vages in the viral polyprotein
@en
type
label
Evidence that the N-terminal d ...... vages in the viral polyprotein
@ast
Evidence that the N-terminal d ...... vages in the viral polyprotein
@en
prefLabel
Evidence that the N-terminal d ...... vages in the viral polyprotein
@ast
Evidence that the N-terminal d ...... vages in the viral polyprotein
@en
P2093
P2860
P1476
Evidence that the N-terminal d ...... vages in the viral polyprotein
@en
P2093
Chambers TJ
Fletterick RJ
McCourt DW
P2860
P304
P407
P577
1990-11-01T00:00:00Z