Guanosine triphosphatase stimulation of oncogenic Ras mutants
about
Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization.Crystal structure of the GTPase-activating protein-related domain from IQGAP1The conformation of bound GMPPNP suggests a mechanism for gating the active site of the SRP GTPaseCrystal structure of Rnd3/RhoE: functional implicationsAlternative splicing of Rac1 generates Rac1b, a self-activating GTPaseK-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactionsMycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motionRegulation of GTPases in the bacterial translation machinery.Concepts in Ras-directed therapy.Prospective Development of Small Molecule Targets to Oncogenic Ras ProteinsProspects for anti-ras drugs.Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation.Total chemical synthesis of a functional interacting protein pair: the protooncogene H-Ras and the Ras-binding domain of its effector c-Raf1.Small-molecule modulation of Ras signaling.Methotrexate and Ras methylation: a new trick for an old drug?Cancer targets in the Ras pathway.Spontaneous nucleotide exchange in low molecular weight GTPases by fluorescently labeled gamma-phosphate-linked GTP analogs.The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivationApproaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007--present).Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities.Pan-selective aptamers for the family of small GTPases.Invited review: Small GTPases and their GAPs.Therapeutic strategies for targeting ras proteins.Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.Genotype and phenotype spectrum of NRAS germline variants.Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.Interaction of a novel fluorescent GTP analogue with the small G-protein K-Ras.Synthesis, characterization and application of two nucleoside triphosphate analogues, GTPgammaNH(2) and GTPgammaF.Comparative functional analysis of the Rac GTPases.Synthesis of GTP-derived Ras ligands.Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction.Monitoring the real-time kinetics of the hydrolysis reaction of guanine nucleotide-binding proteins.
P2860
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P2860
Guanosine triphosphatase stimulation of oncogenic Ras mutants
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Guanosine triphosphatase stimulation of oncogenic Ras mutants
@ast
Guanosine triphosphatase stimulation of oncogenic Ras mutants
@en
Guanosine triphosphatase stimulation of oncogenic Ras mutants
@nl
type
label
Guanosine triphosphatase stimulation of oncogenic Ras mutants
@ast
Guanosine triphosphatase stimulation of oncogenic Ras mutants
@en
Guanosine triphosphatase stimulation of oncogenic Ras mutants
@nl
prefLabel
Guanosine triphosphatase stimulation of oncogenic Ras mutants
@ast
Guanosine triphosphatase stimulation of oncogenic Ras mutants
@en
Guanosine triphosphatase stimulation of oncogenic Ras mutants
@nl
P2093
P2860
P356
P1476
Guanosine triphosphatase stimulation of oncogenic Ras mutants
@en
P2093
A Wittinghofer
K Scheffzek
M R Ahmadian
Z Selinger
P2860
P304
P356
10.1073/PNAS.96.12.7065
P407
P577
1999-06-08T00:00:00Z