Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.
about
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuumIntra-tumor heterogeneity of cancer cells and its implications for cancer treatmentStructure and function of Gab2 and its role in cancer (Review)Juvenile myelomonocytic leukemia: molecular pathogenesis informs current approaches to therapy and hematopoietic cell transplantationImaging flow cytometry: coping with heterogeneity in biological systemsHigh-dimensional single-cell cancer biologyIn silico experimentation of glioma microenvironment development and anti-tumor therapyTumour Heterogeneity: The Key Advantages of Single-Cell AnalysisZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathwayRAS diseases in childrenSrc-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migrationAssociation of reactive oxygen species-mediated signal transduction with in vitro apoptosis sensitivity in chronic lymphocytic leukemia B cellsDistinct patterns of DNA damage response and apoptosis correlate with Jak/Stat and PI3kinase response profiles in human acute myelogenous leukemiaChemical analysis of single cells.Joint modeling and registration of cell populations in cohorts of high-dimensional flow cytometric dataMethods for discovery and characterization of cell subsets in high dimensional mass cytometry dataMultidimensional single cell based STAT phosphorylation profiling identifies a novel biosignature for evaluation of systemic lupus erythematosus activity.STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative diseaseCombined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.Automated identification of stratifying signatures in cellular subpopulationsTargeting CD137 enhances the efficacy of cetuximab.Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities.Clinical proteomics of myeloid leukemia.Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness.B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progressionNovel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms.Development and application of 'phosphoflow' as a tool for immunomonitoringGermline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.Technologies supporting analytical cytology: clinical, research and drug discovery applications.Parametric modeling of cellular state transitions as measured with flow cytometry.From single cells to deep phenotypes in cancer.The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling.GM-CSF-dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia.Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemiaLyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease.NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemiaA CpG-loaded tumor cell vaccine induces antitumor CD4+ T cells that are effective in adoptive therapy for large and established tumors.Development of ultrabright semiconducting polymer dots for ratiometric pH sensing.CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies.
P2860
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P2860
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Single-cell profiling identifi ...... nical and biologic correlates.
@en
type
label
Single-cell profiling identifi ...... nical and biologic correlates.
@en
prefLabel
Single-cell profiling identifi ...... nical and biologic correlates.
@en
P2093
P2860
P1433
P1476
Single-cell profiling identifi ...... nical and biologic correlates.
@en
P2093
Debbie S Sakai
Erin F Simonds
Ernesto Diaz-Flores
Garry P Nolan
Jonathan M Irish
Kevin M Shannon
Marc Coram
Mignon L Loh
Nikesh Kotecha
Nikki J Flores
P2860
P304
P356
10.1016/J.CCR.2008.08.014
P577
2008-10-01T00:00:00Z