Nucleoside hydrolase from Leishmania major. Cloning, expression, catalytic properties, transition state inhibitors, and the 2.5-å crystal structure
about
Purification, characterization, and gene cloning of purine nucleosidase from Ochrobactrum anthropiRecent developments in drug discovery for leishmaniasis and human African trypanosomiasisEnzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivaxThe Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine PhosphorylaseThe Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled OligomerizationStructure and Function of Nucleoside Hydrolases from Physcomitrella patens and Maize Catalyzing the Hydrolysis of Purine, Pyrimidine, and Cytokinin RibosidesSaccharomyces cerevisiae URH1 (encoding uridine-cytidine N-ribohydrolase): functional complementation by a nucleoside hydrolase from a protozoan parasite and by a mammalian uridine phosphorylase.The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsAdaptive immunity against Leishmania nucleoside hydrolase maps its c-terminal domain as the target of the CD4+ T cell-driven protective responseImmucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In VitroImmucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral LeishmaniasisCross-Protective Immunity to Leishmania amazonensis is Mediated by CD4+ and CD8+ Epitopes of Leishmania donovani Nucleoside Hydrolase Terminal DomainsLeishmania donovani Nucleoside Hydrolase Terminal Domains in Cross-Protective Immunotherapy Against Leishmania amazonensis Murine InfectionAmplification of adenine phosphoribosyltransferase suppresses the conditionally lethal growth and virulence phenotype of Leishmania donovani mutants lacking both hypoxanthine-guanine and xanthine phosphoribosyltransferases.The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation.Purine restriction induces pronounced translational upregulation of the NT1 adenosine/pyrimidine nucleoside transporter in Leishmania major.In silico work flow for scaffold hopping in LeishmaniaConstruction of a Saccharomyces cerevisiae strain expressing the Leishmania major nucleoside hydrolase geneAdenine aminohydrolase from Leishmania donovani: unique enzyme in parasite purine metabolismGenetic dissection of pyrimidine biosynthesis and salvage in Leishmania donovani.Purine salvage in Leishmania: complex or simple by design?Expression and purification of an engineered, yeast-expressed Leishmania donovani nucleoside hydrolase with immunogenic propertiesSubstrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs.FML vaccine against canine visceral leishmaniasis: from second-generation to synthetic vaccine.Leishmania donovani Nucleoside Hydrolase (NH36) Domains Induce T-Cell Cytokine Responses in Human Visceral Leishmaniasis.In-silico Leishmania target selectivity of antiparasitic terpenoids.Interactions of antiparasitic alkaloids with Leishmania protein targets: a molecular docking analysis.Pyrimidine-specific ribonucleoside hydrolase from the archaeon Sulfolobus solfataricus--biochemical characterization and homology modeling.Uridine-ribohydrolase is a key regulator in the uridine degradation pathway of Arabidopsis.Analysis of Bacillus anthracis nucleoside hydrolase via in silico docking with inhibitors and molecular dynamics simulation.2'-Deoxyribosyltransferase from Leishmania mexicana, an efficient biocatalyst for one-pot, one-step synthesis of nucleosides from poorly soluble purine bases.The Pseudomonas type III effector HopQ1 activates cytokinin signaling and interferes with plant innate immunity.A conditional mutant deficient in hypoxanthine-guanine phosphoribosyltransferase and xanthine phosphoribosyltransferase validates the purine salvage pathway of Leishmania donovani.A novel nucleoside hydrolase from Lactobacillus buchneri LBK78 catalyzing hydrolysis of 2'-O-methylribonucleosides.
P2860
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P2860
Nucleoside hydrolase from Leishmania major. Cloning, expression, catalytic properties, transition state inhibitors, and the 2.5-å crystal structure
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Nucleoside hydrolase from Leis ...... nd the 2.5-å crystal structure
@ast
Nucleoside hydrolase from Leis ...... nd the 2.5-å crystal structure
@en
Nucleoside hydrolase from Leis ...... nd the 2.5-å crystal structure
@nl
type
label
Nucleoside hydrolase from Leis ...... nd the 2.5-å crystal structure
@ast
Nucleoside hydrolase from Leis ...... nd the 2.5-å crystal structure
@en
Nucleoside hydrolase from Leis ...... nd the 2.5-å crystal structure
@nl
prefLabel
Nucleoside hydrolase from Leis ...... nd the 2.5-å crystal structure
@ast
Nucleoside hydrolase from Leis ...... nd the 2.5-å crystal structure
@en
Nucleoside hydrolase from Leis ...... nd the 2.5-å crystal structure
@nl
P2093
P921
P356
P1476
Nucleoside hydrolase from Leis ...... nd the 2.5-å crystal structure
@en
P2093
P304
P356
10.1074/JBC.274.30.21114
P407
P577
1999-07-23T00:00:00Z