A conditional mutant deficient in hypoxanthine-guanine phosphoribosyltransferase and xanthine phosphoribosyltransferase validates the purine salvage pathway of Leishmania donovani.
about
Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferaseGenetically modified organisms and visceral leishmaniasisAmplification of adenine phosphoribosyltransferase suppresses the conditionally lethal growth and virulence phenotype of Leishmania donovani mutants lacking both hypoxanthine-guanine and xanthine phosphoribosyltransferases.Adaptive responses to purine starvation in Leishmania donovani.Functional characterization of nucleoside transporter gene replacements in Leishmania donovaniSpermidine synthase is required for virulence of Leishmania donovani.IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice.Construction of a Saccharomyces cerevisiae strain expressing the Leishmania major nucleoside hydrolase geneAdenine aminohydrolase from Leishmania donovani: unique enzyme in parasite purine metabolismGenetic dissection of pyrimidine biosynthesis and salvage in Leishmania donovani.GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.Purine salvage in Leishmania: complex or simple by design?Adenylosuccinate synthetase and adenylosuccinate lyase deficiencies trigger growth and infectivity deficits in Leishmania donovani.The cystathionine-β-synthase domains on the guanosine 5''-monophosphate reductase and inosine 5'-monophosphate dehydrogenase enzymes from Leishmania regulate enzymatic activity in response to guanylate and adenylate nucleotide levels.Adenine and adenosine salvage in Leishmania donovani.Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs.Arginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes.Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity.GMP reductase and genetic uncoupling of adenylate and guanylate metabolism in Leishmania donovani parasites.Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.
P2860
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P2860
A conditional mutant deficient in hypoxanthine-guanine phosphoribosyltransferase and xanthine phosphoribosyltransferase validates the purine salvage pathway of Leishmania donovani.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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name
A conditional mutant deficient ...... athway of Leishmania donovani.
@en
A conditional mutant deficient ...... athway of Leishmania donovani.
@nl
type
label
A conditional mutant deficient ...... athway of Leishmania donovani.
@en
A conditional mutant deficient ...... athway of Leishmania donovani.
@nl
prefLabel
A conditional mutant deficient ...... athway of Leishmania donovani.
@en
A conditional mutant deficient ...... athway of Leishmania donovani.
@nl
P2860
P921
P356
P1476
A conditional mutant deficient ...... athway of Leishmania donovani.
@en
P2093
Buddy Ullman
Jan M Boitz
P2860
P304
16084-16089
P356
10.1074/JBC.M600188200
P407
P577
2006-04-08T00:00:00Z