Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
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Structure and functionality in flavivirus NS-proteins: perspectives for drug designHepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5AProtein kinase C-related kinase 2 regulates hepatitis C virus RNA polymerase function by phosphorylationDirect interaction between nucleolin and hepatitis C virus NS5BThe phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transitioncis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genomeHepatitis C virus proteinsA cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replicationComparisons of the M1 genome segments and encoded mu2 proteins of different reovirus isolatesVirologic Tools for HCV Drug Resistance TestingHCV Drug Resistance Challenges in Japan: The Role of Pre-Existing Variants and Emerging Resistant Strains in Direct Acting Antiviral TherapyInhibitors of the Hepatitis C Virus Polymerase; Mode of Action and ResistanceNew era for management of chronic hepatitis C virus using direct antiviral agents: A reviewHepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagyCommon and unique features of viral RNA-dependent polymerasesTemplate/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase.Virus-specific cofactor requirement and chimeric hepatitis C virus/GB virus B nonstructural protein 3Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymeraseMutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymeraseA novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with RibonucleotidesSelection of RNA aptamers that are specific and high-affinity ligands of the hepatitis C virus RNA-dependent RNA polymeraseOligomerization and Cooperative RNA Synthesis Activity of Hepatitis C Virus RNA-Dependent RNA PolymeraseSelection of 3'-template bases and initiating nucleotides by hepatitis C virus NS5B RNA-dependent RNA polymeraseMechanism of de novo initiation by the hepatitis C virus RNA-dependent RNA polymerase: role of divalent metals.Requirements for De Novo Initiation of RNA Synthesis by Recombinant Flaviviral RNA-Dependent RNA PolymerasesCell-free replication of the hepatitis C virus subgenomic replicon.Recombinant viral RdRps can initiate RNA synthesis from circular templates.Molecular virology of hepatitis C virus (HCV): 2006 updateHepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinaseSelection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C VirusA structural and primary sequence comparison of the viral RNA-dependent RNA polymerasesProtein-Protein Interactions between Hepatitis C Virus Nonstructural ProteinsHigh-Affinity Aptamers to Subtype 3a Hepatitis C Virus Polymerase Display Genotypic SpecificityThe C-Terminal Hydrophobic Domain of Hepatitis C Virus RNA Polymerase NS5B Can Be Replaced with a Heterologous Domain of Poliovirus Protein 3ACrystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase EnzymeMechanism of action of a pestivirus antiviral compoundIdentification of a C-Terminal Regulatory Motif in Hepatitis C Virus RNA-Dependent RNA Polymerase: Structural and Biochemical AnalysisMolecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase Inhibitor
P2860
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P2860
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Crystal structure of the RNA-d ...... a fully encircled active site
@ast
Crystal structure of the RNA-d ...... a fully encircled active site
@en
Crystal structure of the RNA-d ...... a fully encircled active site
@nl
type
label
Crystal structure of the RNA-d ...... a fully encircled active site
@ast
Crystal structure of the RNA-d ...... a fully encircled active site
@en
Crystal structure of the RNA-d ...... a fully encircled active site
@nl
prefLabel
Crystal structure of the RNA-d ...... a fully encircled active site
@ast
Crystal structure of the RNA-d ...... a fully encircled active site
@en
Crystal structure of the RNA-d ...... a fully encircled active site
@nl
P2093
P3181
P356
P1476
Crystal structure of the RNA-d ...... a fully encircled active site
@en
P2093
P304
P3181
P356
10.1038/13305
P577
1999-10-01T00:00:00Z