The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures
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Protein prenyltransferasesThe crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimeticsStructure of mammalian protein geranylgeranyltransferase type-IRefinement and prediction of protein prenylation motifsReaction path of protein farnesyltransferase at atomic resolutionStructure of Protein Geranylgeranyltransferase-I from the Human Pathogen Candida albicans Complexed with a Lipid SubstrateCaged Protein Prenyltransferase Substrates: Tools for Understanding Protein PrenylationStructural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein FarnesyltransferaseStructures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal PathogensCrystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug designLysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysisThe CaaX specificities of Arabidopsis protein prenyltransferases explain era1 and ggb phenotypesEngineering protein farnesyltransferase for enzymatic protein labeling applications.Therapeutic intervention based on protein prenylation and associated modificationsSynthesis and conformational analysis of bicyclic extended dipeptide surrogates.Farnesyltransferase--new insights into the zinc-coordination sphere paradigm: evidence for a carboxylate-shift mechanism.Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.Synthetic isoprenoid analogues for the study of prenylated proteins: Fluorescent imaging and proteomic applications.Context-dependent substrate recognition by protein farnesyltransferase.Module assembly for designing multivalent mid-sized inhibitors of protein-protein interactions.Breaking the singleton of germination proteaseFlexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.Substituted imidazo[1,2-a]pyridines as β-strand peptidomimetics.Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity.Computational studies of the farnesyltransferase ternary complex part II: the conformational activation of farnesyldiphosphate.Successful molecular dynamics simulation of the zinc-bound farnesyltransferase using the cationic dummy atom approach.Finding a needle in the haystack: computational modeling of Mg2+ binding in the active site of protein farnesyltransferase.Computational studies of the farnesyltransferase ternary complex part I: substrate binding.Mutagenesis studies of protein farnesyltransferase implicate aspartate beta 352 as a magnesium ligand.Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium.Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras.Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome.Molecular dynamics analysis of a series of 22 potential farnesyltransferase substrates containing a CaaX-motif
P2860
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P2860
The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures
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2000 nî lūn-bûn
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2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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The basis for K-Ras4B binding ...... ion ternary complex structures
@ast
The basis for K-Ras4B binding ...... ion ternary complex structures
@en
The basis for K-Ras4B binding ...... ion ternary complex structures
@nl
type
label
The basis for K-Ras4B binding ...... ion ternary complex structures
@ast
The basis for K-Ras4B binding ...... ion ternary complex structures
@en
The basis for K-Ras4B binding ...... ion ternary complex structures
@nl
prefLabel
The basis for K-Ras4B binding ...... ion ternary complex structures
@ast
The basis for K-Ras4B binding ...... ion ternary complex structures
@en
The basis for K-Ras4B binding ...... ion ternary complex structures
@nl
P2093
P1433
P1476
The basis for K-Ras4B binding ...... ion ternary complex structures
@en
P2093
P304
P356
10.1016/S0969-2126(00)00096-4
P577
2000-02-15T00:00:00Z