The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding
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The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxinStructure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a β-trefoilAccommodation of a highly symmetric core within a symmetric protein superfoldGangliosides as High Affinity Receptors for Tetanus NeurotoxinBotulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent mannerThe biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sitesIdentification of mycobacterial lectins from genomic data.Characterisation of a panel of anti-tetanus toxin single-chain Fvs reveals cooperative bindingNeuronal activity-dependent membrane traffic at the neuromuscular junction.Comparative in vitro and in vivo assessment of toxin neutralization by anti-tetanus toxin monoclonal antibodies.Reduction of the ganglioside binding activity of the tetanus toxin HC fragment destroys immunogenicity: implications for development of novel tetanus vaccines.Structural correlates of carrier protein recognition in tetanus toxoid-conjugated bacterial polysaccharide vaccines.Unique ganglioside binding by botulinum neurotoxins C and D-SAIdentification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.A conformational change of C fragment of tetanus neurotoxin reduces its ganglioside-binding activity but does not destroy its immunogenicity.Using common spatial distributions of atoms to relate functionally divergent influenza virus N10 and N11 protein structures to functionally characterized neuraminidase structures, toxin cell entry domains, and non-influenza virus cell entry domains.Optimization of tetanus toxoid ammonium sulfate precipitation process using response surface methodology.Bacillus subtilis: a temperature resistant and needle free delivery system of immunogens.Bacterial protein toxins and lipids: role in toxin targeting and activity.Receptor and substrate interactions of clostridial neurotoxins.Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permeaseClostridial toxins.Molecular structures and functional relationships in clostridial neurotoxins.Bacterial toxins and the nervous system: neurotoxins and multipotential toxins interacting with neuronal cells.Fragment C of tetanus toxin: new insights into its neuronal signaling pathway.Glyconanoparticles for colorimetric bioassays.Lipid rafts act as specialized domains for tetanus toxin binding and internalization into neuronsClostridium perfringens alpha-toxin recognizes the GM1a-TrkA complex.Cloning, expression, purification, crystallization and preliminary X-ray studies of a secreted lectin (Rv1419) from Mycobacterium tuberculosisC-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neuronsFluorescence emission and polarization analyses for evaluating binding of ruthenium metalloglycoclusters to lectins and tetanus toxin C-fragment.Internalization and retrograde axonal trafficking of tetanus toxin in motor neurons and trans-synaptic propagation at central synapses exceed those of its C-terminal-binding fragments.Detection of bacterial toxins with monosaccharide arrays.Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin.Tyrosine-1290 of tetanus neurotoxin plays a key role in its binding to gangliosides and functional binding to neurones.Sialic acid recognition by Vibrio cholerae neuraminidase.The starch-binding domain as a tool for recombinant protein purification.Asparagine deamidation perturbs antigen presentation on class II major histocompatibility complex molecules.Electrospray mass spectrometry of NeuAc oligomers associated with the C fragment of the tetanus toxin.Two Feet on the Membrane: Uptake of Clostridial Neurotoxins.
P2860
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P2860
The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding
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2000年の論文
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2000年論文
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name
The structures of the H(C) fra ...... sight into ganglioside binding
@ast
The structures of the H(C) fra ...... sight into ganglioside binding
@en
The structures of the H(C) fra ...... sight into ganglioside binding
@nl
type
label
The structures of the H(C) fra ...... sight into ganglioside binding
@ast
The structures of the H(C) fra ...... sight into ganglioside binding
@en
The structures of the H(C) fra ...... sight into ganglioside binding
@nl
prefLabel
The structures of the H(C) fra ...... sight into ganglioside binding
@ast
The structures of the H(C) fra ...... sight into ganglioside binding
@en
The structures of the H(C) fra ...... sight into ganglioside binding
@nl
P2093
P2860
P356
P1476
The structures of the H(C) fra ...... sight into ganglioside binding
@en
P2093
I G Charles
N F Fairweather
N W Isaacs
P2860
P304
P356
10.1074/JBC.275.12.8889
P407
P577
2000-03-24T00:00:00Z