Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B
about
Monitoring tat peptide binding to TAR RNA by solid-state 31P-19F REDOR NMRGuanidinoneomycin B Recognition of an HIV-1 RNA HelixThe apical loop of the HIV-1 TAR RNA hairpin is stabilized by a cross-loop base pairiRED analysis of TAR RNA reveals motional coupling, long-range correlations, and a dynamical hingeTargeting the HIV trans-activation responsive region--approaches towards RNA-binding drugs.Binding sites of the viral RNA element TAR and of TAR mutants for various peptide ligands, probed with LILBID: a new laser mass spectrometry.Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates.Footprinting, circular dichroism and UV melting studies on neomycin B binding to the packaging region of human immunodeficiency virus type-1 RNA.Complete thermodynamic characterization of the multiple protonation equilibria of the aminoglycoside antibiotic paromomycin: a calorimetric and natural abundance 15N NMR study.Ligand-induced changes in 2-aminopurine fluorescence as a probe for small molecule binding to HIV-1 TAR RNAEfficient in silico exploration of RNA interhelical conformations using Euler angles and WExploreRiboswitches: discovery of drugs that target bacterial gene-regulatory RNAs.RNA as a drug target: the case of aminoglycosides.RNA dynamics: perspectives from spin labels.RNA dynamics by design: biasing ensembles towards the ligand-bound state.Using pyrene-labeled HIV-1 TAR to measure RNA-small molecule binding.Development of Small Molecules with a Noncanonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA.Dynamics-based amplification of RNA function and its characterization by using NMR spectroscopy.Characterizing the relative orientation and dynamics of RNA A-form helices using NMR residual dipolar couplings.Multivalent Amino Sugars to Recognize Different TAR RNA Conformations.Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics, and mutagenesisInhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors.New macrocyclic terbium(III) complex for use in RNA footprinting experiments.How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape.Constructing RNA dynamical ensembles by combining MD and motionally decoupled NMR RDCs: new insights into RNA dynamics and adaptive ligand recognition.Insight into the mechanisms of aminoglycoside derivatives interaction with HIV-1 entry steps and viral gene transcription.Domain-elongation NMR spectroscopy yields new insights into RNA dynamics and adaptive recognition.Shortening the HIV-1 TAR RNA Bulge by a Single Nucleotide Preserves Motional Modes over a Broad Range of Time Scales.NMR studies of nucleic acid dynamicsRiboswitch-based antibacterial drug discovery using high-throughput screening methods.Cleavage of RNA oligonucleotides by aminoglycosides.Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble.The bulge region of HIV-1 TAR RNA binds metal ions in solution.A high-throughput drug screening system for HIV-1 transcription inhibitors.Analyzing the flexibility of RNA structures by constraint counting.Molecular dynamics simulations identify time scale of conformational changes responsible for conformational selection in molecular recognition of HIV-1 transactivation responsive RNA.TAR-RNA recognition by a novel cyclic aminoglycoside analogue.Probing Na(+)-induced changes in the HIV-1 TAR conformational dynamics using NMR residual dipolar couplings: new insights into the role of counterions and electrostatic interactions in adaptive recognition.Evidence that electrostatic interactions dictate the ligand-induced arrest of RNA global flexibility.Inhibition of bacterial RNase P by aminoglycoside-arginine conjugates.
P2860
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P2860
Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B
description
2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2000 թվականի հուլիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B
@ast
Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B
@en
Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B
@nl
type
label
Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B
@ast
Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B
@en
Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B
@nl
prefLabel
Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B
@ast
Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B
@en
Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B
@nl
P2860
P356
P1476
Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B
@en
P2093
P2860
P304
P356
10.1074/JBC.M000920200
P407
P577
2000-07-07T00:00:00Z