Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP
about
Structure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 functionSolvent effect on the folding dynamics and structure of E6-associated protein characterized from ab initio protein folding simulations.The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosis.HPV E6, E6AP and cervical cancer.The full-length isoform of human papillomavirus 16 E6 and its splice variant E6* bind to different sites on the procaspase 8 death effector domain.Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain.Identification and characterization of small molecule human papillomavirus E6 inhibitorsA mutant of human papillomavirus type 16 E6 deficient in binding alpha-helix partners displays reduced oncogenic potential in vivo.A conserved amphipathic helix in the N-terminal regulatory region of the papillomavirus E1 helicase is required for efficient viral DNA replication.The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivo.Small molecule inhibitors of human papillomavirus protein - protein interactions.Folding and misfolding of the papillomavirus E6 interacting peptide E6ap.Molecular Probing of the HPV-16 E6 Protein Alpha Helix Binding Groove with Small Molecule Inhibitors.Recent advances in the search for antiviral agents against human papillomaviruses.Cellular binding partners of the human papillomavirus E6 protein.The interaction between human papillomavirus type 16 and FADD is mediated by a novel E6 binding domain.Papillomavirus E6 proteins.Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins.The active form of E6-associated protein (E6AP)/UBE3A ubiquitin ligase is an oligomer.The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoprotein.Determinants of stability for the E6 protein of papillomavirus type 16.Association of papillomavirus E6 proteins with either MAML1 or E6AP clusters E6 proteins by structure, function, and evolutionary relatedness.Small Scaffolds, Big Potential: Developing Miniature Proteins as Therapeutic Agents.
P2860
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P2860
Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Solution structure determinati ...... E6 interacting peptide of E6AP
@ast
Solution structure determinati ...... E6 interacting peptide of E6AP
@en
Solution structure determinati ...... E6 interacting peptide of E6AP
@nl
type
label
Solution structure determinati ...... E6 interacting peptide of E6AP
@ast
Solution structure determinati ...... E6 interacting peptide of E6AP
@en
Solution structure determinati ...... E6 interacting peptide of E6AP
@nl
prefLabel
Solution structure determinati ...... E6 interacting peptide of E6AP
@ast
Solution structure determinati ...... E6 interacting peptide of E6AP
@en
Solution structure determinati ...... E6 interacting peptide of E6AP
@nl
P2093
P356
P1433
P1476
Solution structure determinati ...... E6 interacting peptide of E6AP
@en
P2093
P304
P356
10.1021/BI0019592
P407
P577
2001-02-06T00:00:00Z