Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins.
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Sonoporation delivery of monoclonal antibodies against human papillomavirus 16 E6 restores p53 expression in transformed cervical keratinocytesStructure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 functionFlavonol and imidazole derivatives block HPV16 E6 activities and reactivate apoptotic pathways in HPV⁺ cellsPapillomavirus E6 oncoproteins.In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.HPV E6, E6AP and cervical cancer.GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers.Identification and characterization of small molecule human papillomavirus E6 inhibitorsNew molecular targets against cervical cancer.Emerging drugs to treat squamous cell carcinomas of the head and neck.Small molecule inhibitors of human papillomavirus protein - protein interactions.Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteins.Molecular Probing of the HPV-16 E6 Protein Alpha Helix Binding Groove with Small Molecule Inhibitors.Recent advances in the search for antiviral agents against human papillomaviruses.Targeting human papillomavirus genome replication for antiviral drug discoveryWild-type p53 reactivation by small-molecule Minnelide™ in human papillomavirus (HPV)-positive head and neck squamous cell carcinoma.Cellular binding partners of the human papillomavirus E6 protein.Modulation of apoptotic pathways by human papillomaviruses (HPV): mechanisms and implications for therapy.The interaction between human papillomavirus type 16 and FADD is mediated by a novel E6 binding domain.Molecular characterization of head and neck cancer: how close to personalized targeted therapy?A novel intracellular antibody against the E6 oncoprotein impairs growth of human papillomavirus 16-positive tumor cells in mouse models.Emerging biological treatments for uterine cervical carcinoma.Emerging drugs for cervical cancer.The role of human papillomavirus in nongenital cancers.HPV E6 oncoprotein as a potential therapeutic target in HPV related cancers.Emerging drugs for the treatment of cervical cancer.Human papilloma virus 16 E6 protein as a target for curcuminoids, curcumin conjugates and congeners for chemoprevention of oral and cervical cancers.Binding of human papillomavirus type 16 E6 to E6AP is not required for activation of hTERTEnhanced biosynthetically directed fractional carbon-13 enrichment of proteins for backbone NMR assignments.A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells.
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Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 21 April 2006
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Identification of inhibitors t ...... tures of interacting proteins.
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Identification of inhibitors t ...... tures of interacting proteins.
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type
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Identification of inhibitors t ...... tures of interacting proteins.
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Identification of inhibitors t ...... tures of interacting proteins.
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Identification of inhibitors t ...... tures of interacting proteins.
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Identification of inhibitors t ...... tures of interacting proteins.
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P2093
P2860
P1433
P1476
Identification of inhibitors t ...... tures of interacting proteins.
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P2093
Elliot J Androphy
James D Baleja
Jason J Chen
Johannes H Voigt
Jonathan J Cherry
Marc C Nicklaus
Zhiguo Liu
P2860
P356
10.1016/J.ANTIVIRAL.2006.03.014
P577
2006-04-21T00:00:00Z