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Dynamic properties of the Ras switch I region and its importance for binding to effectors

Dynamic properties of the Ras switch I region and its importance for binding to effectors

http://www.wikidata.org/entity/Q27631350

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Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loop The centaurin gamma-1 GTPase-like domain functions as an NTPase Rac-mediated Stimulation of Phospholipase Cγ2 Amplifies B Cell Receptor-induced Calcium Signaling.Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamics Long-distance conformational changes in a protein engineered by modulated sequence duplication Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase Effector Proteins Exert an Important Influence on the Signaling-active State of the Small GTPase Cdc42 Structural basis of GDP release and gating in G protein coupled Fe2+ transport Allosteric modulation of Ras positions Q61 for a direct role in catalysis Structural Basis for Conformational Dynamics of GTP-bound Ras Protein Ras Homolog Enriched in Brain (Rheb) Enhances Apoptotic Signaling Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity Analysis of Binding Site Hot Spots on the Surface of Ras GTPase Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants Structural insights into the small G-protein Arl13B and implications for Joubert syndrome A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction.Molecular Mechanism for Conformational Dynamics of Ras·GTP Elucidated from In-Situ Structural Transition in Crystal Retrotransposition and mutation events yield Rap1 GTPases with differential signalling capacity Drosophila Rab23 is involved in the regulation of the number and planar polarization of the adult cuticular hairs.Obligatory role in GTP hydrolysis for the amide carbonyl oxygen of the Mg(2+)-coordinating Thr of regulatory GTPases Dual modes of cdc42 recycling fine-tune polarized morphogenesis.Mechanism of the exchange reaction in HRAS from multiscale modeling Slow, reversible, coupled folding and binding of the spectrin tetramerization domain.Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases.Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases.The mutational landscapes of genetic and chemical models of Kras-driven lung cancer The change of protein intradomain mobility on ligand binding: is it a commonly observed phenomenon?A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein A switch I mutant of Cdc42 exhibits less conformational freedom.Small-molecule modulation of Ras signaling.A modified infrared spectrometer with high time resolution and its application for investigating fast conformational changes of the GTPase Ras.Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers Site-specific processing of Ras and Rap1 Switch I by a MARTX toxin effector domain.Relevance of the kinetic equilibrium of forces to the control of the cell cycle by Ras proteins.Revealing conformational substates of lipidated N-Ras protein by pressure modulation.Intragenic suppressor mutations restore GTPase and translation functions of a eukaryotic initiation factor 5B switch II mutant.

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P2860

Dynamic properties of the Ras switch I region and its importance for binding to effectors

http://www.wikidata.org/entity/Q27631350

description

2001 nî lūn-bûn

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2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2001 թվականի ապրիլին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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Dynamic properties of the Ras switch I region and its importance for binding to effectors

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Dynamic properties of the Ras switch I region and its importance for binding to effectors

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Dynamic properties of the Ras switch I region and its importance for binding to effectors

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Dynamic properties of the Ras switch I region and its importance for binding to effectors

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Dynamic properties of the Ras switch I region and its importance for binding to effectors

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Dynamic properties of the Ras switch I region and its importance for binding to effectors

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Dynamic properties of the Ras switch I region and its importance for binding to effectors

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Dynamic properties of the Ras switch I region and its importance for binding to effectors

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Dynamic properties of the Ras switch I region and its importance for binding to effectors

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Proceedings of the National Academy of Sciences of the United States of America

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Dynamic properties of the Ras switch I region and its importance for binding to effectors

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A Wittinghofer

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C Herrmann

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H R Kalbitzer

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I R Vetter

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M Spoerner

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P2860

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

Ras/Rap effector specificity determined by charge reversal

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein

Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling

Structural basis for the interaction of Ras with RalGDS

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10.1073/PNAS.081441398

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11320243

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33143

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