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Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

http://www.wikidata.org/entity/Q27674432

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RAS isoforms and mutations in cancer at a glance pMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound Proteins Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motions Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs.Mechanism of the exchange reaction in HRAS from multiscale modeling Drugging the undruggable RAS: Mission possible?How proteins bind macrocycles.Binding hotspots on K-ras: consensus ligand binding sites and other reactive regions from probe-based molecular dynamics analysis.Ligand deconstruction: Why some fragment binding positions are conserved and others are not New Frontiers in Druggability Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding Overview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras.Inhibition of prenylated KRAS in a lipid environment Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate.Focused grid-based resampling for protein docking and mapping.Relationship between hot spot residues and ligand binding hot spots in protein-protein interfaces.Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function.KRAS - An Evolving Cancer Target NRAS germline variant G138R and multiple rare somatic mutations on APC in colorectal cancer patients in Taiwan by next generation sequencing.Driving Structure-Based Drug Discovery through Cosolvent Molecular Dynamics.Computational allosteric ligand binding site identification on Ras proteins.Analysis of correlated mutations in Ras G-domain.The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution.Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction from Ras to Ral.Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition.Study of the correlation between H-ras mutation and primary hepatocellular carcinoma Ras: structural details to guide direct targeting.Allosteric activation of the Par-6 PDZ via a partial unfolding transition.Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations.Exploring the structural origins of cryptic sites on proteins.

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P2860

Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

http://www.wikidata.org/entity/Q27674432

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2011 nî lūn-bûn

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2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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name

Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

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Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

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Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

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Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

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Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

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Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

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Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

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Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

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Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

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J.JMB.2011.09.011

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Journal of Molecular Biology

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Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

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Bradley M Kearney

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Brandon Zerbe

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Carla Mattos

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Casey O'Connor

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Elizaveta A Kovrigina

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Evgenii L Kovrigin

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Greg Buhrman

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Raeanne Napoleon

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Sandor Vajda

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P2860

A novel switch region regulates H-ras membrane orientation and signal output

Ras/Rap effector specificity determined by charge reversal

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

The structural basis of the activation of Ras by Sos

Structural conservation of druggable hot spots in protein-protein interfaces

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structural view of the Ran-Importin beta interaction at 2.3 A resolution

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

Dynamic properties of the Ras switch I region and its importance for binding to effectors

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