Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer
about
T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformationSevere combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3T cell activationStructural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC DiscriminationMechanical regulation of T-cell functionsA conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signalingForce generation upon T cell receptor engagementStructural and Functional Evidence that Nck Interaction with CD3ε Regulates T-Cell Receptor ActivityRegulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based MotifT Cell Receptors are Structures Capable of Initiating Signaling in the Absence of Large Conformational RearrangementsA Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR DimerizationStructure of the Chicken CD3 / Heterodimer and Its Assembly with the T Cell ReceptorAn allosteric site in the T-cell receptor Cβ domain plays a critical signalling role.Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors.The organizing principle in the formation of the T cell receptor-CD3 complex.Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.Molecular architecture of the αβ T cell receptor-CD3 complex.Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.Flanking V and J sequences of complementary determining region 3 of T cell receptor (TCR) δ1 (CDR3δ1) determine the structure and function of TCRγ4δ1Roles of TGF-β/Smad signaling pathway in pathogenesis and development of gluteal muscle contracture.Molecular mechanisms for the assembly of the T cell receptor-CD3 complex.Facilitating matched pairing and expression of TCR chains introduced into human T cells.A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor.Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.Involvement of the TCR Cbeta FG loop in thymic selection and T cell function.A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinaseTwisting tails exposed: the evidence for TCR conformational changeA role for "self" in T-cell activationThe alphabeta T cell receptor is an anisotropic mechanosensor.Mechanochemitry: a molecular biomechanics view of mechanosensing.Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling.TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity.The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function.Early T-cell activation biophysics.The Stalk Domain of NKp30 Contributes to Ligand Binding and Signaling of a Preassembled NKp30-CD3ζ Complex.
P2860
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P2860
Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Mechanisms contributing to T c ...... CD3 epsilon gamma heterodimer
@ast
Mechanisms contributing to T c ...... CD3 epsilon gamma heterodimer
@en
Mechanisms contributing to T c ...... CD3 epsilon gamma heterodimer
@nl
type
label
Mechanisms contributing to T c ...... CD3 epsilon gamma heterodimer
@ast
Mechanisms contributing to T c ...... CD3 epsilon gamma heterodimer
@en
Mechanisms contributing to T c ...... CD3 epsilon gamma heterodimer
@nl
prefLabel
Mechanisms contributing to T c ...... CD3 epsilon gamma heterodimer
@ast
Mechanisms contributing to T c ...... CD3 epsilon gamma heterodimer
@en
Mechanisms contributing to T c ...... CD3 epsilon gamma heterodimer
@nl
P2093
P1433
P1476
Mechanisms contributing to T c ...... CD3 epsilon gamma heterodimer
@en
P2093
P304
P356
10.1016/S0092-8674(01)00395-6
P407
P577
2001-06-01T00:00:00Z