A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase
about
Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesThe Cbl interactome and its functionsOrganization of proximal signal initiation at the TCR:CD3 complex.c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway.Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell developmentIntramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.Cbl enforces Vav1 dependence and a restricted pathway of T cell developmentLoss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomyRapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.Indispensable roles of mammalian Cbl family proteins as negative regulators of protein tyrosine kinase signaling: Insights from in vivo modelsRegulation of T cell development by c-Cbl: essential role of Lck.c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.Alpha-MSH regulates protein ubiquitination in T cells.Lymphocyte signaling: beyond knockouts.Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses.Rapid microtubule-dependent induction of neurite-like extensions in NIH 3T3 fibroblasts by inhibition of ROCK and Cblc-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 arrestZAP-70: an essential kinase in T-cell signalingCbl-family proteins as regulators of cytoskeleton-dependent phenomena.Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation.Cbl-mediated ubiquitinylation and negative regulation of Vav.c-Cbl negatively regulates platelet activation by glycoprotein VI.Feedback regulation of RTK signaling in development.Modeling CBL activating mutations in vivo.
P2860
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P2860
A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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name
A mouse with a loss-of-functio ...... of the ZAP-70 tyrosine kinase
@ast
A mouse with a loss-of-functio ...... of the ZAP-70 tyrosine kinase
@en
type
label
A mouse with a loss-of-functio ...... of the ZAP-70 tyrosine kinase
@ast
A mouse with a loss-of-functio ...... of the ZAP-70 tyrosine kinase
@en
prefLabel
A mouse with a loss-of-functio ...... of the ZAP-70 tyrosine kinase
@ast
A mouse with a loss-of-functio ...... of the ZAP-70 tyrosine kinase
@en
P2093
P2860
P356
P1476
A mouse with a loss-of-functio ...... of the ZAP-70 tyrosine kinase
@en
P2093
Christine B F Thien
David D L Bowtell
John M Papadimitriou
Maria A Murphy
Robin M Scaife
Wallace Y Langdon
P2860
P304
P356
10.1084/JEM.20021498
P407
P577
2003-02-01T00:00:00Z