Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate
about
Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteinsWhy boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiationAndrogen biosynthesis in castration-resistant prostate cancerBile acid binding protein: a versatile host of small hydrophobic ligands for applications in the fields of MRI contrast agents and bio-nanomaterialsCrystal Structure of Human Liver 4-3-Ketosteroid 5 -Reductase (AKR1D1) and Implications for Substrate Binding and CatalysisConversion of Human Steroid 5 -Reductase (AKR1D1) into 3 -Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERINGFjord-region benzo[g]chrysene-11,12-dihydrodiol and benzo[c]phenanthrene-3,4-dihydrodiol as substrates for rat liver dihydrodiol dehydrogenase (AKR1C9): structural basis for stereochemical preferenceModeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice.Characterization of disease-related 5beta-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiency.Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamilySteroid hormone transforming aldo-keto reductases and cancer.Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.Crystallization and preliminary X-ray diffraction analysis of mouse prostaglandin F2α synthase, AKR1B3.Promiscuity and diversity in 3-ketosteroid reductases.Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.Pre-receptor regulation of the androgen receptorMultiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens.Current physico-biochemistry in steroid research and status of structural biology for steroid-converting enzymes.Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3).Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen.
P2860
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P2860
Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Crystal structure of human typ ...... h NADP(+) and ursodeoxycholate
@ast
Crystal structure of human typ ...... h NADP(+) and ursodeoxycholate
@en
Crystal structure of human typ ...... h NADP(+) and ursodeoxycholate
@nl
type
label
Crystal structure of human typ ...... h NADP(+) and ursodeoxycholate
@ast
Crystal structure of human typ ...... h NADP(+) and ursodeoxycholate
@en
Crystal structure of human typ ...... h NADP(+) and ursodeoxycholate
@nl
prefLabel
Crystal structure of human typ ...... h NADP(+) and ursodeoxycholate
@ast
Crystal structure of human typ ...... h NADP(+) and ursodeoxycholate
@en
Crystal structure of human typ ...... h NADP(+) and ursodeoxycholate
@nl
P2093
P356
P1433
P1476
Crystal structure of human typ ...... h NADP(+) and ursodeoxycholate
@en
P2093
P304
10161-10168
P356
10.1021/BI010919A
P407
P577
2001-08-01T00:00:00Z