Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia
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Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitorsStructures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinasesInsights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structuresX-ray crystal structure of bone marrow kinase in the x chromosome: a Tec family kinaseRegulatory phosphorylation of Ikaros by Bruton's tyrosine kinaseConformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering.Characterization of all possible single-nucleotide change caused amino acid substitutions in the kinase domain of Bruton tyrosine kinase.Structure-based reassessment of the caveolin signaling model: do caveolae regulate signaling through caveolin-protein interactions?Characterization of pathogenic germline mutations in human protein kinases.A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation.Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.Identification of an allosteric signaling network within Tec family kinases.Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells.Bruton's TK inhibitors: structural insights and evolution of clinical candidates.Types and effects of protein variations.The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinibDynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.Receptor-guided 3D-QSAR studies, molecular dynamics simulation and free energy calculations of Btk kinase inhibitorsNovel Bruton's tyrosine kinase inhibitors currently in development.αC helix as a switch in the conformational transition of Src/CDK-like kinase domains.A new autoinhibited kinase conformation reveals a salt-bridge switch in kinase activation.Clinical potential of targeting Bruton's tyrosine kinase.Conformational snapshots of Tec kinases during signaling.Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity.Bruton tyrosine kinase (BTK) and its role in B-cell malignancy.Targeting the unactivated conformations of protein kinases for small molecule drug discovery.B-cell receptor signaling inhibitors for treatment of autoimmune inflammatory diseases and B-cell malignancies.Bruton's tyrosine kinase--an integral protein of B cell development that also has an essential role in the innate immune system.Breaking good: the inexorable rise of BTK inhibitors in the treatment of chronic lymphocytic leukaemia.The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy.Consequences of two naturally occurring missense mutations in the structure and function of Bruton agammaglobulinemia tyrosine kinase.Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Naturally occurring Bruton's tyrosine kinase mutations have no dominant negative effect in an X-linked agammaglobulinaemia cellular model.Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families.Role of the PHTH module in protein substrate recognition by Bruton's agammaglobulinemia tyrosine kinase.Defective expression of Bruton's tyrosine kinase in acute lymphoblastic leukemia.Scaffold mining of kinase hinge binders in crystal structure database.Molecular modeling studies on series of Btk inhibitors using docking, structure-based 3D-QSAR and molecular dynamics simulation: a combined approach.
P2860
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P2860
Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Crystal structure of Bruton's ...... of X-linked agammaglobulinemia
@ast
Crystal structure of Bruton's ...... of X-linked agammaglobulinemia
@en
Crystal structure of Bruton's ...... of X-linked agammaglobulinemia
@nl
type
label
Crystal structure of Bruton's ...... of X-linked agammaglobulinemia
@ast
Crystal structure of Bruton's ...... of X-linked agammaglobulinemia
@en
Crystal structure of Bruton's ...... of X-linked agammaglobulinemia
@nl
prefLabel
Crystal structure of Bruton's ...... of X-linked agammaglobulinemia
@ast
Crystal structure of Bruton's ...... of X-linked agammaglobulinemia
@en
Crystal structure of Bruton's ...... of X-linked agammaglobulinemia
@nl
P2093
P2860
P3181
P356
P1476
Crystal structure of Bruton's ...... of X-linked agammaglobulinemia
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.M104828200
P407
P577
2001-11-02T00:00:00Z