Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases - Wikidata - wikimedia - TriplyDB

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

http://www.wikidata.org/entity/Q27658863

about

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures Active site profiling reveals coupling between domains in SRC-family kinases Molecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and Coevolution Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors.Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.T-cell signaling regulated by the Tec family kinase, Itk.Identification of an allosteric signaling network within Tec family kinases.Can structural features of kinase receptors provide clues on selectivity and inhibition? A molecular modeling study Prolonged and tunable residence time using reversible covalent kinase inhibitors.Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.Receptor-guided 3D-QSAR studies, molecular dynamics simulation and free energy calculations of Btk kinase inhibitors Novel Bruton's tyrosine kinase inhibitors currently in development.αC helix as a switch in the conformational transition of Src/CDK-like kinase domains.A hexylchloride-based catch-and-release system for chemical proteomic applications.Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes Design, Synthesis, and Evaluation of Dasatinib-Amino Acid and Dasatinib-Fatty Acid Conjugates as Protein Tyrosine Kinase Inhibitors.Structure-functional prediction and analysis of cancer mutation effects in protein kinases.Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignancies.Specificity rendering 'hot-spots' for aurora kinase inhibitor design: the role of non-covalent interactions and conformational transitions.Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL.X-linked agammaglobulinemia presenting as polymicrobial pneumonia, including Pneumocystis jirovecii.A selective NMR probe to monitor the conformational transition from inactive to active kinase.Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ.A switch in nucleotide affinity governs activation of the Src and Tec family kinases.Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases.Discovery of Novel Bruton's Tyrosine Kinase (BTK) Inhibitors Bearing a N,9-Diphenyl-9H-purin-2-amine Scaffold.A Specific and Covalent JNK-1 Ligand Selected from an Encoded Self-Assembling Chemical Library.Millisecond dynamics of BTK reveal kinome-wide conformational plasticity within the apo kinase domain.Role of Bruton's tyrosine kinase in B cells and malignancies.NF-κB signaling and its relevance to the treatment of mantle cell lymphoma.

P2860

Q24633214-C4E36CED-163D-4B65-827C-6529B23431ED Q27666787-39AD556C-F589-4762-98F5-F690B105D305 Q27675080-05B67314-4B8E-4EE9-8D9F-8F96F43C50CE Q28548366-6E30319B-38D0-43F7-BD24-EE13EC199719 Q30009417-0B87A9B3-53CA-4A22-BC62-0CB7BE77A861 Q33874259-93997B11-E478-49A0-8938-31F7F2D70562 Q33931933-0A013567-8B0F-4A83-B3CB-BCC870B2517C Q34172793-27753EBB-10B1-42FD-BA7A-3173ACCE654B Q35181207-FAF2CC85-DF05-4915-895C-35E2BD780A00 Q35756228-C7552904-3B4A-4AAA-9D7D-A451F542B1EF Q35968819-42ECB7D2-477C-475A-AF69-317F374F8764 Q36329533-8BD5B1D2-D97E-49CC-B1E2-62A9C571BC9D Q36673755-03D66353-9EB2-4AF9-A274-486ABEF15976 Q36779990-827FA8F2-921C-467E-B9AE-913892D141CE Q36781195-C2D299DC-AEB9-4A6C-8B5B-52626C155405 Q37226729-FB5EC372-BB9D-4FAE-9B2F-4A2C521FA9EF Q38729630-A99F24EB-07FD-4E9A-A55B-54FE0C4665E0 Q38987589-364E7410-C79C-49D1-9989-5957EE09820F Q41524241-C428A3E3-88A5-4D47-9260-9C0F83E9DF94 Q41717003-FF35AC4C-950B-4814-8049-696C8F8E50A5 Q42315534-485A4E4E-5C5A-45A8-ADB6-8FF435105486 Q42770597-692E9A7C-8C67-430F-AE55-5F9D11DAEC70 Q43113518-2F92CC11-2F88-4AA2-9CD4-92818402025D Q46244831-208D9CE7-2EA5-4780-AD0E-EAF26F2F5306 Q47119217-165B5E0B-C917-42F1-B7C5-097AAA154A51 Q47769000-D2397E37-9D1E-40AD-B450-DA779D434EA3 Q48016248-5503229E-14ED-46DA-AD35-F5FF8B0FA4EB Q48172577-13E2DDD5-4BB0-418F-AE14-9AF635367C5B Q48296795-5A264BAD-3D5C-4483-AA71-7CA9059FE465 Q49888075-13FBEDF1-5594-4F5D-9FA7-A16C2D4EE476 Q55427997-3A5C07D3-23D9-458C-B685-ECDACAD04A6E

P2860

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

http://www.wikidata.org/entity/Q27658863

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մարտին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Structures of human Bruton's t ...... ivation for TEC family kinases

@ast

Structures of human Bruton's t ...... ivation for TEC family kinases

@en

Structures of human Bruton's t ...... ivation for TEC family kinases

@nl

type

label

Structures of human Bruton's t ...... ivation for TEC family kinases

@ast

Structures of human Bruton's t ...... ivation for TEC family kinases

@en

Structures of human Bruton's t ...... ivation for TEC family kinases

@nl

prefLabel

Structures of human Bruton's t ...... ivation for TEC family kinases

@ast

Structures of human Bruton's t ...... ivation for TEC family kinases

@en

Structures of human Bruton's t ...... ivation for TEC family kinases

@nl

P1433

Q27658863-15DD107E-54FF-4784-A7E6-A12C6380A319

P1476

Q27658863-04224370-E195-4CF7-BCB7-61797C5E9D14

P2093

Q27658863-35703231-5F1B-4CFA-8891-F1FCB4A0C9FC

Q27658863-5D1FB9E9-FC53-4FE1-A3AE-BD125B90550F

Q27658863-5D3EC1F5-9F44-4F32-BABF-FC4889CBB955

Q27658863-84172F59-6D56-41E3-BD5B-A95B7A7B86CF

Q27658863-985ADAA4-CCAC-40BC-9525-A121FC249A46

Q27658863-AD700AAD-E486-45B7-9946-793DCE9461C8

Q27658863-B0522A53-E49A-4477-8302-16662D18E86A

Q27658863-B1A1FD22-C363-486D-824F-45F198BA0999

Q27658863-B27A5B87-4B73-45E1-9BCC-65A5330333AA

Q27658863-C2927B14-F86B-4852-B3B5-7A65BBB5A693

P2860

Q27658863-00AE89AF-F41F-48DA-8A8E-C4876B10BF44

Q27658863-024B6589-3047-4F80-953C-33BF0E2DFFF5

Q27658863-09C0BF51-88CB-4534-B466-B2545B96A5E0

Q27658863-12B0D4DD-A48E-4441-8406-0B182A7D6A51

Q27658863-17CE10C2-FD3E-4388-AA89-67977F1A95A1

Q27658863-271D23B9-87E8-4399-BF0D-A3A4E3CF111A

Q27658863-34898110-9C52-41C4-9769-FEA286CC1FE3

Q27658863-35881BEA-4D4A-4064-9AD4-ECF914AD8FE9

Q27658863-35BBC6B8-C3E1-43F0-BFB0-199EE76A87FF

Q27658863-3BDEE262-2595-4A07-92D5-2AEB9A1E1EBA

P304

Q27658863-741E0041-A828-4452-B6D5-5181CD9E8F5B

P31

Q27658863-87AA560E-FD45-42F7-84E3-CE4067E21F2A

P3181

Q27658863-4FF67AED-B87C-4FCF-83E7-C59CFCDF4A16

P356

Q27658863-01B34109-857E-42D8-9CBF-8084E2928955

P433

Q27658863-08B93BDB-5C2C-4EAA-900E-0AD36D6AA7A5

P478

Q27658863-3AF66C7F-267A-43D8-A9B2-861E9B0DE888

P577

Q27658863-EB9F7606-8444-47B2-BC34-37E300BBC9AD

P5875

Q27658863-8F4D7D24-4351-4D02-BDA9-1EE07B57EC70

P698

Q27658863-A2FC2198-7588-430A-BB91-400412A97AB8

P932

Q27658863-F992D0F1-3283-4CA9-BDAC-C156B5B8C25B

P3181

P356

P1433

Protein Science

P1476

Structures of human Bruton's t ...... ivation for TEC family kinases

@en

P2093

Brian T Hopkins

http://www.w3.org/2001/XMLSchema#string

Catherine A Hession

http://www.w3.org/2001/XMLSchema#string

Craig P Wildes

http://www.w3.org/2001/XMLSchema#string

Darren P Baker

http://www.w3.org/2001/XMLSchema#string

Douglas J Marcotte

http://www.w3.org/2001/XMLSchema#string

Elisabeth Mertsching

http://www.w3.org/2001/XMLSchema#string

Konrad Miatkowski

http://www.w3.org/2001/XMLSchema#string

Laura F Silvian

http://www.w3.org/2001/XMLSchema#string

Michael J Romanowski

http://www.w3.org/2001/XMLSchema#string

Patrick F Cullen

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia

Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors

Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state

Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc

Coot: model-building tools for molecular graphics

Searching protein structure databases with DaliLite v.3

Refinement of macromolecular structures by the maximum-likelihood method

An approach to multi-copy search in molecular replacement

Calculation of protein extinction coefficients from amino acid sequence data

P304

429-39

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

5070837

http://www.w3.org/2001/XMLSchema#string

P356

10.1002/PRO.321

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

19

http://www.w3.org/2001/XMLSchema#string

P577

2010-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

40851527

http://www.w3.org/2001/XMLSchema#string

P698

20052711

http://www.w3.org/2001/XMLSchema#string

P932

2866269

http://www.w3.org/2001/XMLSchema#string