Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity - Wikidata - wikimedia - TriplyDB

Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity

Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity

http://www.wikidata.org/entity/Q27635130

about

DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway Osteoclasts: what do they do and how do they do it?Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation Principles of antibody-mediated TNF receptor activation Mycobacterium tuberculosis Chaperonin 10 Heptamers Self-Associate through Their Biologically Active Loops Structure-based development of a receptor activator of nuclear factor- B ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions Interleukin-11 receptor signaling is required for normal bone remodeling Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).Mutations within the TNF-like core domain of RANKL impair osteoclast differentiation and activation Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.Osteoclasts and odontoclasts: signaling pathways to development and disease.Denosumab mimics the natural decoy receptor osteoprotegerin by interacting with its major binding site on RANKL.Manipulation of receptor oligomerization as a strategy to inhibit signaling by TNF superfamily members A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss Osteoclasts; culprits in inflammatory osteolysis.Tumour necrosis factor superfamily cytokines and the pathogenesis of inflammatory osteolysis Bone destruction in arthritis.Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics.Variants of Osteoprotegerin Lacking TRAIL Binding for Therapeutic Bone Remodeling in Osteolytic Malignancies.Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways.A RANKL mutant used as an inter-species vaccine for efficient immunotherapy of osteoporosis.Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease.RANKL cytokine: from pioneer of the osteoimmunology era to cure for a rare disease RANK, RANKL and osteoprotegerin in bone biology and disease.Crystallization and preliminary X-ray analysis of mouse RANK and its complex with RANKL RANKing c-Jun in osteoclast development.RANK/RANKL: regulators of immune responses and bone physiology.A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke.Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors.New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis.Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial 'human osteoclastology'.The role of T-cell leukemia translocation-associated gene protein in human tumorigenesis and osteoclastogenesis.Denosumab for treatment of breast cancer bone metastases and beyond.Functionality of Intrinsic Disorder in Tumor Necrosis Factor-α and its Receptors.Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts - Crucial 'Human Osteoclastology'.Inflammatory osteolysis: a conspiracy against bone.

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Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity

http://www.wikidata.org/entity/Q27635130

description

2001 nî lūn-bûn

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2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2001 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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Crystal structure of the TRANC ...... of receptor-ligand specificity

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Crystal structure of the TRANC ...... of receptor-ligand specificity

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Crystal structure of the TRANC ...... of receptor-ligand specificity

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type

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Crystal structure of the TRANC ...... of receptor-ligand specificity

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Crystal structure of the TRANC ...... of receptor-ligand specificity

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Crystal structure of the TRANC ...... of receptor-ligand specificity

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Crystal structure of the TRANC ...... of receptor-ligand specificity

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Crystal structure of the TRANC ...... of receptor-ligand specificity

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Crystal structure of the TRANC ...... of receptor-ligand specificity

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Journal of Clinical Investigation

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Crystal structure of the TRANC ...... of receptor-ligand specificity

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C A Nelson

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D H Fremont

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F P Ross

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J Lam

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S L Teitelbaum

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P2860

Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

RANK is essential for osteoclast and lymph node development

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity

Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation

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crystal structure

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200957

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