Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site
about
Purine bases at position 37 of tRNA stabilize codon-anticodon interaction in the ribosomal A site by stacking and Mg2+-dependent interactions.Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscodingTwo conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site.Recent Advances in Developing Small Molecules Targeting Nucleic AcidRecent developments in drug discovery for leishmaniasis and human African trypanosomiasisAntibiotics that target protein synthesisThe crystal structure of an alternating RNA heptamer r(GUAUACA) forming a six base-paired duplex with 3'-end adenine overhangsEncapsulating streptomycin within a small 40-mer RNABreaking pseudo-twofold symmetry in the poliovirus 3'-UTR Y-stem by restoring Watson-Crick base pairsThe bacterial and mitochondrial ribosomal A-site molecular switches possess different conformational substatesStructure of the cytosine-cytosine mismatch in the thymidylate synthase mRNA binding site and analysis of its interaction with the aminoglycoside paromomycinA model for the study of ligand binding to the ribosomal RNA helix h44Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analoguesA structural basis for the antibiotic resistance conferred by an A1408G mutation in 16S rRNA and for the antiprotozoal activity of aminoglycosidesIdentification of the molecular attributes required for aminoglycoside activity against LeishmaniaDissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycinCrystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sitesNovel methyltransferase for modified uridine residues at the wobble position of tRNA.Translational roles of elongation factor 2 protein lysine methylationEnhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae.Stm1p alters the ribosome association of eukaryotic elongation factor 3 and affects translation elongationThe bacterial ribosome as a target for antibioticsInterplay of the bacterial ribosomal A-site, S12 protein mutations and paromomycin binding: a molecular dynamics study.Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics.Global epigenetic changes induced by SWI2/SNF2 inhibitors characterize neomycin-resistant mammalian cells.Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical diseaseLocal RNA structural changes induced by crystallization are revealed by SHAPEAssociation of aminoglycosidic antibiotics with the ribosomal A-site studied with Brownian dynamicsMolecular dynamics study of the ribosomal A-site.Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity.Comparing aminoglycoside binding sites in bacterial ribosomal RNA and aminoglycoside modifying enzymes.Disaccharide mimetics of the aminoglycoside antibiotic neamine.Fluorescent pyrimidine ribonucleotide: synthesis, enzymatic incorporation, and utilization.Search for novel aminoglycosides by combining fragment-based virtual screening and 3D-QSAR scoring5-methylcytosine in RNA: detection, enzymatic formation and biological functions.Binding of aminoglycoside antibiotics to helix 69 of 23S rRNAFootprinting, circular dichroism and UV melting studies on neomycin B binding to the packaging region of human immunodeficiency virus type-1 RNA.The non-Watson-Crick base pairs and their associated isostericity matrices.Understanding the origins of bacterial resistance to aminoglycosides through molecular dynamics mutational study of the ribosomal A-site.Structural analysis of base substitutions in Thermus thermophilus 16S rRNA conferring streptomycin resistance.
P2860
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P2860
Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site
@ast
Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site
@en
Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site
@nl
type
label
Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site
@ast
Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site
@en
Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site
@nl
prefLabel
Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site
@ast
Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site
@en
Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site
@nl
P3181
P1433
P1476
Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site
@en
P2093
P304
P3181
P356
10.1016/S0969-2126(01)00629-3
P577
2001-08-01T00:00:00Z