2.4 A crystal structure of an oxaliplatin 1,2-d(GpG) intrastrand cross-link in a DNA dodecamer duplex
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Chiral discrimination in platinum anticancer drugs.2.4-A crystal structure of the asymmetric platinum complex [Pt(ammine)(cyclohexylamine)]2+ bound to a dodecamer DNA duplexSolution Structures of a DNA Dodecamer Duplex with and without a Cisplatin 1,2-d(GG) Intrastrand Cross-Link: Comparison with the Same DNA Duplex Containing an Oxaliplatin 1,2-d(GG) Intrastrand Cross-Link † , ‡Site selectivity of platinum anticancer therapeuticscis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospectsStructure of duplex DNA containing the cisplatin 1,2-{Pt(NH3)2}2+-d(GpG) cross-link at 1.77Å resolutionSpecific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generationFlanking Bases Influence the Nature of DNA Distortion by Platinum 1,2-Intrastrand (GG) Cross-LinksStructure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligandStructural basis of human DNA polymerase η-mediated chemoresistance to cisplatin.An Organometallic Compound which Exhibits a DNA Topology-Dependent One-Stranded Intercalation ModeThe Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) ProdrugsAnalysis of structural flexibility of damaged DNA using thiol-tethered oligonucleotide duplexesDisturbance of DNA conformation by the binding of testosterone-based platinum drugs via groove-face and intercalative interactions: a molecular dynamics simulation study.Unusual DNA binding modes for metal anticancer complexes.The phosphate clamp: a small and independent motif for nucleic acid backbone recognitionExcursions in polynuclear platinum DNA binding.Synthesis, characterization, and cytotoxicity of platinum(IV) carbamate complexesOxaliplatin and its enantiomer induce different condensation dynamics of single DNA molecules{(1R,2R,4R)-4-methyl-1,2-cyclohexanediamine}oxalatoplatinum(II): a novel enantiomerically pure oxaliplatin derivative showing improved anticancer activity in vivo.Rationally designed oxaliplatin-nanoparticle for enhanced antitumor efficacyCisplatin induces loop structures and condensation of single DNA molecules.Structural basis for the sequence-dependent effects of platinum-DNA adducts.Debio 0507 primarily forms diaminocyclohexane-Pt-d(GpG) and -d(ApG) DNA adducts in HCT116 cells.Investigations of the binding of [Pt2(DTBPA)Cl2](II) and [Pt2(TPXA)Cl2](II) to DNA via various cross-linking modes.Inhibition of transcription by platinum antitumor compoundsDifferences in conformational dynamics of [Pt3(HPTAB)]6+-DNA adducts with various cross-linking modesOrganic cation transporters are determinants of oxaliplatin cytotoxicity.Synthetic methods for the preparation of platinum anticancer complexes.Analytical methodologies for metallomics studies of antitumor Pt-containing drugs.Coordination chemistry beyond Werner: interplay between hydrogen bonding and coordination.DNA synthesis inhibitors for the treatment of gastrointestinal cancer.Kinetics of cisplatin binding to short r(GG) containing miRNA mimics - influence of Na(+)versus K(+), temperature and hydrophobicity on reactivity.Preventing oxaliplatin-induced neurotoxicity: rationale and design of phase Ib randomized, double-blind, placebo-controlled, cross-over trials for early clinical evaluation of investigational therapeutics.Visible-light-induced annihilation of tumor cells with platinum-porphyrin conjugates.trans,cis,cis-bis(benzoato)dichlorido(cyclohexane-1R,2R-diamine)platinum(IV): a prodrug candidate for the treatment of oxaliplatin-refractory colorectal cancer.Synthesis of antitumor azolato-bridged dinuclear platinum(ii) complexes with in vivo antitumor efficacy and unique in vitro cytotoxicity profiles.Atomic level rendering of DNA-drug encounter.Speciation of oxaliplatin adducts with DNA nucleotides.Gold(I) complexes of water-soluble diphos-type ligands: synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition.
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P2860
2.4 A crystal structure of an oxaliplatin 1,2-d(GpG) intrastrand cross-link in a DNA dodecamer duplex
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2001 nî lūn-bûn
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2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年論文
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2001年論文
@zh-hant
2001年論文
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2001年論文
@zh-mo
2001年論文
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2001年论文
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name
2.4 A crystal structure of an ...... link in a DNA dodecamer duplex
@ast
2.4 A crystal structure of an ...... link in a DNA dodecamer duplex
@en
2.4 A crystal structure of an ...... link in a DNA dodecamer duplex
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type
label
2.4 A crystal structure of an ...... link in a DNA dodecamer duplex
@ast
2.4 A crystal structure of an ...... link in a DNA dodecamer duplex
@en
2.4 A crystal structure of an ...... link in a DNA dodecamer duplex
@nl
prefLabel
2.4 A crystal structure of an ...... link in a DNA dodecamer duplex
@ast
2.4 A crystal structure of an ...... link in a DNA dodecamer duplex
@en
2.4 A crystal structure of an ...... link in a DNA dodecamer duplex
@nl
P2093
P356
P1433
P1476
2.4 A crystal structure of an ...... link in a DNA dodecamer duplex
@en
P2093
B Spingler
D A Whittington
S J Lippard
P304
P356
10.1021/IC010790T
P407
P577
2001-10-22T00:00:00Z