Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design
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Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoniImaging Sites of Inhibition of Proteolysis in Pathomimetic Human Breast Cancer Cultures by Light-Activated Ruthenium CompoundA geometry force field which converts low-resolution X-ray models to structures with properties found at ultra high resolutionIdentification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays.Computational analysis of the cathepsin B inhibitors activities through LR-MMPBSA binding affinity calculation based on docked complex.QSAR models for predicting cathepsin B inhibition by small molecules--continuous and binary QSAR models to classify cathepsin B inhibition activities of small molecules.Light activation of a cysteine protease inhibitor: caging of a peptidomimetic nitrile with Ru(II)(bpy)2Inhibition of cathepsin activity in a cell-based assay by a light-activated ruthenium compound.Multi-conformation 3D QSAR study of benzenesulfonyl-pyrazol-ester compounds and their analogs as cathepsin B inhibitors.Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection.Coordinating activation strategy for C(sp(3))-H/C(sp(3))-H cross-coupling to access β-aromatic α-amino acidsOxygen additions in serial femtosecond crystallographic protein structures.Targeting Cathepsin B for Cancer Therapies.Photoactivated inhibition of cathepsin K in a 3D tumor model.Cathepsin B Inhibitors: Combining Dipeptide Nitriles with an Occluding Loop Recognition Element by Click Chemistry.Cathepsins in digestive cancers.Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin B by 1,2,4-thiadiazole derivatives.Highly selective aza-nitrile inhibitors for cathepsin K, structural optimization and molecular modeling.Ru(ii) polypyridyl complexes as photocages for bioactive compounds containing nitriles and aromatic heterocycles.Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability.Advances in the discovery of cathepsin K inhibitors on bone resorption.
P2860
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P2860
Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design
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2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Identification of dipeptidyl n ...... gh structure-based drug design
@ast
Identification of dipeptidyl n ...... gh structure-based drug design
@en
Identification of dipeptidyl n ...... gh structure-based drug design
@nl
type
label
Identification of dipeptidyl n ...... gh structure-based drug design
@ast
Identification of dipeptidyl n ...... gh structure-based drug design
@en
Identification of dipeptidyl n ...... gh structure-based drug design
@nl
prefLabel
Identification of dipeptidyl n ...... gh structure-based drug design
@ast
Identification of dipeptidyl n ...... gh structure-based drug design
@en
Identification of dipeptidyl n ...... gh structure-based drug design
@nl
P2093
P356
P1476
Identification of dipeptidyl n ...... gh structure-based drug design
@en
P2093
D L Farley
J H van Duzer
J R Doughty
L W McQuire
P304
P356
10.1021/JM010206Q
P407
P577
2001-12-20T00:00:00Z