Interhelical interactions in the gp41 core: implications for activation of HIV-1 membrane fusion
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HIV-1 envelope glycoprotein structureDiscovery of Critical Residues for Viral Entry and Inhibition through Structural Insight of HIV-1 Fusion Inhibitor CP621-652HIV-1 gp41 and gp160 are hyperthermostable proteins in a mesophilic environment. Characterization of gp41 mutants.Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection.Identification of the HIV-1 gp41 core-binding motif in the scaffolding domain of caveolin-1.Structure-based design, synthesis and biological evaluation of new N-carboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41.Human immunodeficiency virus (HIV) gp41 escape mutants: cross-resistance to peptide inhibitors of HIV fusion and altered receptor activation of gp120.Amino acid 36 in the human immunodeficiency virus type 1 gp41 ectodomain controls fusogenic activity: implications for the molecular mechanism of viral escape from a fusion inhibitorSubunit organization of the membrane-bound HIV-1 envelope glycoprotein trimerThe conserved residue Arg46 in the N-terminal heptad repeat domain of HIV-1 gp41 is critical for viral fusion and entryIncreasing hydrophobicity of residues in an anti-HIV-1 Env peptide synergistically improves potencyHIV-1 envelope accessible surface and polarity: clade, blood, and brain.Human immunodeficiency virus type 1 variants resistant to first- and second-version fusion inhibitors and cytopathic in ex vivo human lymphoid tissue.Significant differences in cell-cell fusion and viral entry between strains revealed by scanning mutagenesis of the C-heptad repeat of HIV gp41Peptide mimic of the HIV envelope gp120-gp41 interfaceA vaccine strategy against AIDS: an HIV gp41 peptide immunization prevents NKp44L expression and CD4+ T cell depletion in SHIV-infected macaquesRole of hydrophobic residues in the central ectodomain of gp41 in maintaining the association between human immunodeficiency virus type 1 envelope glycoprotein subunits gp120 and gp41.Computer-Aided Approaches for Targeting HIVgp41.The six-helix bundle of human immunodeficiency virus Env controls pore formation and enlargement and is initiated at residues proximal to the hairpin turnConserved salt bridge between the N- and C-terminal heptad repeat regions of the human immunodeficiency virus type 1 gp41 core structure is critical for virus entry and inhibition.The fusion activity of HIV-1 gp41 depends on interhelical interactions.NMR second site screening for structure determination of ligands bound in the hydrophobic pocket of HIV-1 gp41.The role of amphiphilicity and negative charge in glycoprotein 41 interactions in the hydrophobic pocket.Conserved residue Lys574 in the cavity of HIV-1 Gp41 coiled-coil domain is critical for six-helix bundle stability and virus entry.Prefusion rearrangements resulting in fusion Peptide exposure in Semliki forest virus.HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to human brain microvascular endothelial cells via gp41 core-induced membrane activities.Structurally altered peptides reveal an important role for N-terminal heptad repeat binding and stability in the inhibitory action of HIV-1 peptide DP178.
P2860
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P2860
Interhelical interactions in the gp41 core: implications for activation of HIV-1 membrane fusion
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2002 nî lūn-bûn
@nan
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Interhelical interactions in t ...... ation of HIV-1 membrane fusion
@ast
Interhelical interactions in t ...... ation of HIV-1 membrane fusion
@en
Interhelical interactions in t ...... ation of HIV-1 membrane fusion
@nl
type
label
Interhelical interactions in t ...... ation of HIV-1 membrane fusion
@ast
Interhelical interactions in t ...... ation of HIV-1 membrane fusion
@en
Interhelical interactions in t ...... ation of HIV-1 membrane fusion
@nl
prefLabel
Interhelical interactions in t ...... ation of HIV-1 membrane fusion
@ast
Interhelical interactions in t ...... ation of HIV-1 membrane fusion
@en
Interhelical interactions in t ...... ation of HIV-1 membrane fusion
@nl
P2093
P356
P1433
P1476
Interhelical interactions in t ...... ation of HIV-1 membrane fusion
@en
P2093
Jack H Nunberg
Joanne York
Marisa O Stoller
Shilong Wang
P304
P356
10.1021/BI025648Y
P407
P577
2002-06-11T00:00:00Z