Crystal structure of HslUV complexed with a vinyl sulfone inhibitor: corroboration of a proposed mechanism of allosteric activation of HslV by HslU
about
Insights into the molecular evolution of HslU ATPase through biochemical and mutational analysesThe AAA+ superfamily of functionally diverse proteinsStructures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine.Structural insights into the conformational diversity of ClpP from Bacillus subtilisStructural and Biochemical Analyses of the Eukaryotic Heat Shock Locus V (HslV) from Trypanosoma bruceiPaddling mechanism for the substrate translocation by AAA+ motor revealed by multiscale molecular simulations.Nucleotide-dependent substrate recognition by the AAA+ HslUV protease.Sculpting the proteome with AAA(+) proteases and disassembly machines.Molecular machines for protein degradation.Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase.Binding of MG132 or deletion of the Thr active sites in HslV subunits increases the affinity of HslV protease for HslU ATPase and makes this interaction nucleotide-independent.HslVU ATP-dependent protease utilizes maximally six among twelve threonine active sites during proteolysisMini review: ATP-dependent proteases in bacteria.Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease.Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease.Control of substrate gating and translocation into ClpP by channel residues and ClpX binding.Asymmetric nucleotide transactions of the HslUV protease.The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring.Molecular modeling studies of the interaction between Plasmodium falciparum HslU and HslV subunits.Communication between ClpX and ClpP during substrate processing and degradation.Covalently linked HslU hexamers support a probabilistic mechanism that links ATP hydrolysis to protein unfolding and translocation.Classifying and assembling two-dimensional X-ray laser diffraction patterns of a single particle to reconstruct the three-dimensional diffraction intensity function: resolution limit due to the quantum noise.
P2860
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P2860
Crystal structure of HslUV complexed with a vinyl sulfone inhibitor: corroboration of a proposed mechanism of allosteric activation of HslV by HslU
description
2002 nî lūn-bûn
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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2002 թվականի մայիսին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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name
Crystal structure of HslUV com ...... ric activation of HslV by HslU
@ast
Crystal structure of HslUV com ...... ric activation of HslV by HslU
@en
Crystal structure of HslUV com ...... ric activation of HslV by HslU
@nl
type
label
Crystal structure of HslUV com ...... ric activation of HslV by HslU
@ast
Crystal structure of HslUV com ...... ric activation of HslV by HslU
@en
Crystal structure of HslUV com ...... ric activation of HslV by HslU
@nl
prefLabel
Crystal structure of HslUV com ...... ric activation of HslV by HslU
@ast
Crystal structure of HslUV com ...... ric activation of HslV by HslU
@en
Crystal structure of HslUV com ...... ric activation of HslV by HslU
@nl
P1476
Crystal structure of HslUV com ...... ric activation of HslV by HslU
@en
P2093
David B McKay
Marcelo C Sousa
P304
P356
10.1016/S0022-2836(02)00145-6
P407
P577
2002-05-03T00:00:00Z