Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity
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Structural and molecular evolutionary analysis of Agouti and Agouti-related proteinsDesign, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptorLoop-Swapped Chimeras of the Agouti-Related Protein and the Agouti Signaling Protein Identify Contacts Required for Melanocortin 1 Receptor Selectivity and AntagonismThe potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug deliveryEvolution of a horizontally acquired legume gene, albumin 1, in the parasitic plant Phelipanche aegyptiaca and related species.Alternative binding proteins: biological activity and therapeutic potential of cystine-knot miniproteins.Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities.Knottin cyclization: impact on structure and dynamics.Cystine-knot peptides engineered with specificities for α(IIb)β(3) or α(IIb)β(3) and α(v)β(3) integrins are potent inhibitors of platelet aggregation.Evaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrinTransient ectopic overexpression of agouti-signalling protein 1 (asip1) induces pigment anomalies in flatfish.Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptorsEngineering agatoxin, a cystine-knot peptide from spider venom, as a molecular probe for in vivo tumor imagingCyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptorsDiscovery of a β-Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology.Agouti-related protein segments outside of the receptor binding core are required for enhanced short- and long-term feeding stimulation111In-labeled cystine-knot peptides based on the Agouti-related protein for targeting tumor angiogenesis.A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands.The agouti-related peptide binds heparan sulfate through segments critical for its orexigenic effects.The role of the Agouti-Related Protein in energy balance regulation.Cystine-knot peptides: emerging tools for cancer imaging and therapy.Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists.Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist PharmacologSynthetic Cystine-Knot Miniproteins - Valuable Scaffolds for Polypeptide Engineering.
P2860
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P2860
Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Design, pharmacology, and NMR ...... gouti-related protein activity
@ast
Design, pharmacology, and NMR ...... gouti-related protein activity
@en
Design, pharmacology, and NMR ...... gouti-related protein activity
@nl
type
label
Design, pharmacology, and NMR ...... gouti-related protein activity
@ast
Design, pharmacology, and NMR ...... gouti-related protein activity
@en
Design, pharmacology, and NMR ...... gouti-related protein activity
@nl
prefLabel
Design, pharmacology, and NMR ...... gouti-related protein activity
@ast
Design, pharmacology, and NMR ...... gouti-related protein activity
@en
Design, pharmacology, and NMR ...... gouti-related protein activity
@nl
P2093
P921
P356
P1433
P1476
Design, pharmacology, and NMR ...... gouti-related protein activity
@en
P2093
Biaoxin Chai
Darren A Thompson
Glenn L Millhauser
Gregory S Barsh
Joseph C McNulty
Pilgrim J Jackson
Ying-Kui Yang
P304
P356
10.1021/BI012000X
P407
P577
2002-06-18T00:00:00Z