The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery
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Design, Synthesis, Structural and Functional Characterization of Novel Melanocortin Agonists Based on the Cyclotide Kalata B1Antimicrobial Peptides from PlantsFragmentation follows structure: top-down mass spectrometry elucidates the topology of engineered cystine-knot miniproteinsAlternative binding proteins: biological activity and therapeutic potential of cystine-knot miniproteins.Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities.Knottin cyclization: impact on structure and dynamics.Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.Cyclotides, a promising molecular scaffold for peptide-based therapeutics.Cystine-knot peptides engineered with specificities for α(IIb)β(3) or α(IIb)β(3) and α(v)β(3) integrins are potent inhibitors of platelet aggregation.Protease-resistant peptide ligands from a knottin scaffold library.A Bioengineered Peptide that Localizes to and Illuminates Medulloblastoma: A New Tool with Potential for Fluorescence-Guided Surgical ResectionSolution structure of a sponge-derived cystine knot peptide and its notable stability.Asteropsins B-D, sponge-derived knottins with potential utility as a novel scaffold for oral peptide drugsEvaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrinA biochemical guide to yeast adhesins: glycoproteins for social and antisocial occasionsEngineering agatoxin, a cystine-knot peptide from spider venom, as a molecular probe for in vivo tumor imagingCombinatorial optimization of cystine-knot peptides towards high-affinity inhibitors of human matriptase-1Cystine-knot peptides targeting cancer-relevant human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).Genome-Wide Reprogramming of Transcript Architecture by Temperature Specifies the Developmental States of the Human Pathogen Histoplasma.The Cystine Knot Is Responsible for the Exceptional Stability of the Insecticidal Spider Toxin ω-Hexatoxin-Hv1aKNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007High Proteolytic Resistance of Spider-Derived Inhibitor Cystine KnotsPotential therapeutic applications of the cyclotides and related cystine knot mini-proteins.99mTc-labeled cystine knot peptide targeting integrin αvβ6 for tumor SPECT imaging.Engineered cystine-knot miniproteins for diagnostic applications.Cyclotides: a patent review.Cyclotides as grafting frameworks for protein engineering and drug design applications.Cystine-knot peptides: emerging tools for cancer imaging and therapy.A chemically cross-linked knottin dimer binds integrins with picomolar affinity and inhibits tumor cell migration and proliferation.Computational analysis of the MCoTI-II plant defence knottin reveals a novel intermediate conformation that facilitates trypsin binding.In vitro-engineered non-antibody protein therapeutics.Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists.Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation.Intramolecular thioether crosslinking of therapeutic proteins to increase proteolytic stability.Synthetic Cystine-Knot Miniproteins - Valuable Scaffolds for Polypeptide Engineering.
P2860
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P2860
The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery
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2006 nî lūn-bûn
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2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2006 թվականի ապրիլին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The potential of cystine-knot ...... in oral peptide drug delivery
@ast
The potential of cystine-knot ...... in oral peptide drug delivery
@en
The potential of cystine-knot ...... in oral peptide drug delivery
@nl
type
label
The potential of cystine-knot ...... in oral peptide drug delivery
@ast
The potential of cystine-knot ...... in oral peptide drug delivery
@en
The potential of cystine-knot ...... in oral peptide drug delivery
@nl
prefLabel
The potential of cystine-knot ...... in oral peptide drug delivery
@ast
The potential of cystine-knot ...... in oral peptide drug delivery
@en
The potential of cystine-knot ...... in oral peptide drug delivery
@nl
P2093
P2860
P1476
The potential of cystine-knot ...... in oral peptide drug delivery
@en
P2093
Alexander Wentzel
Harald Kolmar
Hong-Lei Huang
Martin Werle
Thierry Schmitz
P2860
P304
P356
10.1080/10611860600648254
P407
P577
2006-04-01T00:00:00Z