Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation
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The RCSB Protein Data Bank: redesigned web site and web servicesLengsin Is a Survivor of an Ancient Family of Class I Glutamine Synthetases Re-engineered by Evolution for a Role in the Vertebrate LensStructure and Dynamics of UDP–Glucose Pyrophosphorylase from Arabidopsis thaliana with Bound UDP–Glucose and UTPEnsemble Refinement of Protein Crystal Structures: Validation and ApplicationCrystallographic Analysis of a Sex-Specific Enhancer Element: Sequence-Dependent DNA Structure, Hydration, and DynamicsThe structures of cytosolic and plastid-located glutamine synthetases fromMedicago truncatulareveal a common and dynamic architectureFunctional analysis of GlnE, an essential adenylyl transferase in Mycobacterium tuberculosisAll four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasisKinetic and structural insights into the mechanism of AMPylation by VopS Fic domainDevelopment of a simple assay protocol for high-throughput screening of Mycobacterium tuberculosis glutamine synthetase for the identification of novel inhibitors.Development of a simple high-throughput screening protocol based on biosynthetic activity of Mycobacterium tuberculosis glutamine synthetase for the identification of novel Inhibitors.Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights.Functional roles of the conserved Glu304 loop of Bacillus subtilis glutamine synthetaseTipping the balance by manipulating post-translational modifications.Feedback-resistant mutations in Bacillus subtilis glutamine synthetase are clustered in the active site.Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601.A Modified Bacillus Calmette-Guérin (BCG) Vaccine with Reduced Activity of Antioxidants and Glutamine Synthetase Exhibits Enhanced Protection of Mice despite Diminished in Vivo Persistence.Glutamine synthetase in legumes: recent advances in enzyme structure and functional genomics.Inhibition of glutamine synthetase: a potential drug target in Mycobacterium tuberculosis.Cloning, molecular characterization, and phylogeny of two evolutionary distinct glutamine synthetase isoforms in the green microalga Haematococcus pluvialis (Chlorophyceae).Crystallization and preliminary crystallographic characterization of glutamine synthetase from Medicago truncatula.Adenylylation and catalytic properties of Mycobacterium tuberculosis glutamine synthetase expressed in Escherichia coli versus mycobacteria.A feedback-resistant mutant of Bacillus subtilis glutamine synthetase with pleiotropic defects in nitrogen-regulated gene expression.Reaction Mechanism of Mycobacterium Tuberculosis Glutamine Synthetase Using Quantum Mechanics/Molecular Mechanics Calculations.Chemoselective generation of acyl phosphates, acylium ion equivalents, from carboxylic acids and an organophosphate ester in the presence of a Brønsted acid.Diazotrophic Growth Allows Azotobacter vinelandii To Overcome the Deleterious Effects of a glnE Deletion.Electrophilic activation of aminocarboxylic acid by phosphate ester promotes Friedel-Crafts acylation by overcoming charge-charge repulsion.A core of three amino acids at the carboxyl-terminal region of glutamine synthetase defines its regulation in cyanobacteriaStructural Analysis of Glutamine Synthetase from Helicobacter pylori
P2860
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P2860
Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation
description
2002 nî lūn-bûn
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2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Multicopy crystallographic ref ...... c mechanism and its regulation
@ast
Multicopy crystallographic ref ...... c mechanism and its regulation
@en
Multicopy crystallographic ref ...... c mechanism and its regulation
@nl
type
label
Multicopy crystallographic ref ...... c mechanism and its regulation
@ast
Multicopy crystallographic ref ...... c mechanism and its regulation
@en
Multicopy crystallographic ref ...... c mechanism and its regulation
@nl
prefLabel
Multicopy crystallographic ref ...... c mechanism and its regulation
@ast
Multicopy crystallographic ref ...... c mechanism and its regulation
@en
Multicopy crystallographic ref ...... c mechanism and its regulation
@nl
P356
P1433
P1476
Multicopy crystallographic ref ...... c mechanism and its regulation
@en
P2093
Gaston M U Pfluegl
Harindarpal S Gill
P304
P356
10.1021/BI020254S
P407
P577
2002-08-06T00:00:00Z