Structural basis for Chk1 inhibition by UCN-01 - Wikidata - wikimedia - TriplyDB

Structural basis for Chk1 inhibition by UCN-01

Structural basis for Chk1 inhibition by UCN-01

http://www.wikidata.org/entity/Q27639676

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Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine Chromosome breakage after G2 checkpoint release Alternative binding modes of an inhibitor to two different kinases Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition Structures of 5-methylthioribose kinase reveal substrate specificity and unusual mode of nucleotide binding Structural and Functional Characterization of the Human Protein Kinase ASK1 Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors Crystal structure of domain-swapped STE20 OSR1 kinase domain A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons Host modulators of H1N1 cytopathogenicity The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain The effects of G2-phase enrichment and checkpoint abrogation on low-dose hyper-radiosensitivity Constitutive autophagy in plant root cells.Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): optimization and selectivity profiling.Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo Autorepression of rfx1 gene expression: functional conservation from yeast to humans in response to DNA replication arrest.The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A.A chemical genomic study identifying diversity in cell migration signaling in cancer cells.Indolocarbazole natural products: occurrence, biosynthesis, and biological activity.Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells.Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents.DockBench: An Integrated Informatic Platform Bridging the Gap between the Robust Validation of Docking Protocols and Virtual Screening Simulations.Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors Chk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling.Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein.A novel Chk1-binding peptide that enhances genotoxic sensitivity through the cellular redistribution of nuclear Chk1.ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity.Reconstitution of modular PDK1 functions on trans-splicing of the regulatory PH and catalytic kinase domains Protein kinase C, an elusive therapeutic target?p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.Marine pyrrolocarbazoles and analogues: synthesis and kinase inhibition.Checkpoint kinase 1 negatively regulates somatic hypermutation.Personalized Medicine and Resurrected Hopes for the Management of Alzheimer's Disease: A Modular Approach Based on GSK-3β Inhibitors.Therapeutic potential of investigational CHK-1 inhibitors for the treatment of solid tumors.Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiating cell fraction.Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1.A robust, target-driven, cell-based assay for checkpoint kinase 1 inhibitors.

P2860

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P2860

Structural basis for Chk1 inhibition by UCN-01

http://www.wikidata.org/entity/Q27639676

description

2002 nî lūn-bûn

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2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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name

Structural basis for Chk1 inhibition by UCN-01

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Structural basis for Chk1 inhibition by UCN-01

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Structural basis for Chk1 inhibition by UCN-01

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type

label

Structural basis for Chk1 inhibition by UCN-01

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Structural basis for Chk1 inhibition by UCN-01

@en

Structural basis for Chk1 inhibition by UCN-01

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prefLabel

Structural basis for Chk1 inhibition by UCN-01

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Structural basis for Chk1 inhibition by UCN-01

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Structural basis for Chk1 inhibition by UCN-01

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P1433

Journal of Biological Chemistry

P1476

Structural basis for Chk1 inhibition by UCN-01

@en

P2093

Baoguang Zhao

http://www.w3.org/2001/XMLSchema#string

Bin-Bing S Zhou

http://www.w3.org/2001/XMLSchema#string

Huizhen Zhao

http://www.w3.org/2001/XMLSchema#string

Kyung O Johanson

http://www.w3.org/2001/XMLSchema#string

Michael J Bower

http://www.w3.org/2001/XMLSchema#string

Nestor O Concha

http://www.w3.org/2001/XMLSchema#string

Patrick J McDevitt

http://www.w3.org/2001/XMLSchema#string

Stephen T Davis

http://www.w3.org/2001/XMLSchema#string

Susan M Green

http://www.w3.org/2001/XMLSchema#string

P2860

The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.

Improved methods for building protein models in electron density maps and the location of errors in these models

PROCHECK: a program to check the stereochemical quality of protein structures

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation

Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

Checkpoints: controls that ensure the order of cell cycle events

The DNA damage response: putting checkpoints in perspective

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

Areas, volumes, packing and protein structure

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46609-15

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scholarly article

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3237888

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10.1074/JBC.M201233200

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P433

48

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277

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2002-11-29T00:00:00Z

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12244092

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