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Intra-lesional injection of the novel PKC activator EBC-46 rapidly ablates tumors in mouse modelsAXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomasPKCδ stabilizes TAp63 to promote cell apoptosisA unified approach to the important protein kinase inhibitor balanol and a proposed analoguePancreatic β Cell Mass DeathROS and ROS-Mediated Cellular SignalingNew Drugs from Marine Organisms in Alzheimer's DiseaseTargeting Protein Kinase C Downstream of Growth Factor and Adhesion SignallingRho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseaseA role of WT1 in cell division and genomic stabilityThe Novel PKCθ from Benchtop to ClinicRaf-interactome in tuning the complexity and diversity of Raf function.Arginase induction and activation during ischemia and reperfusion and functional consequences for the heartProtein kinase C in the immune system: from signalling to chromatin regulationmTOR signaling in tumorigenesisInterplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failureCryptocaryol Structure-Activity Relationship Study of Cancer Cell Cytotoxicity and Ability to Stabilize PDCD4An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patientsMouse Sphingosine Kinase 1a Is Negatively Regulated through Conventional PKC-Dependent Phosphorylation at S373 ResidueProtein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain.Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitorsThe Concise Guide to PHARMACOLOGY 2013/14: enzymes.C2-domain mediated nano-cluster formation increases calcium signaling efficiency.Correcting mitochondrial fusion by manipulating mitofusin conformations.Protein Kinases C-Mediated Regulations of Drug Transporter Activity, Localization and Expression.Adducin is required for desmosomal cohesion in keratinocytes.Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy.Protein kinase C inhibitor chelerythrine selectively inhibits proliferation of triple-negative breast cancer cells.Novel small molecule inhibiting CDCP1-PKCδ pathway reduces tumor metastasis and proliferation.PKC-η-MARCKS Signaling Promotes Intracellular Survival of Unopsonized Burkholderia thailandensisThe total synthesis of K-252c (staurosporinone) via a sequential C-H functionalisation strategy.Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR)cPKC regulates interphase nuclear size during Xenopus development.MicroRNA-200b suppresses arsenic-transformed cell migration by targeting protein kinase Cα and Wnt5b-protein kinase Cα positive feedback loop and inhibiting Rac1 activationInteractions of protein kinase C-α C1A and C1B domains with membranes: a combined computational and experimental study.Protein kinase Cδ is a therapeutic target in malignant melanoma with NRAS mutation.MicroRNA-200b targets protein kinase Cα and suppresses triple-negative breast cancer metastasisA high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor.Novel mechanism of impaired function of organic anion-transporting polypeptide 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2012
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Protein kinase C, an elusive therapeutic target?
@en
Protein kinase C, an elusive therapeutic target?
@nl
type
label
Protein kinase C, an elusive therapeutic target?
@en
Protein kinase C, an elusive therapeutic target?
@nl
prefLabel
Protein kinase C, an elusive therapeutic target?
@en
Protein kinase C, an elusive therapeutic target?
@nl
P2860
P356
P1476
Protein kinase C, an elusive therapeutic target?
@en
P2093
Kevin V Grimes
P2860
P2888
P304
P356
10.1038/NRD3871
P577
2012-12-01T00:00:00Z