Crystal structures of a pantothenate synthetase fromM. tuberculosisand its complexes with substrates and a reaction intermediate
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Inhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction IntermediateA Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial ChemistryX-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoateOptimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery against Mycobacterium tuberculosis Pantothenate SynthetaseIntegrated biophysical approach to fragment screening and validation for fragment-based lead discoveryA high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosisPurification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetaseReaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase.Biosynthesis of Pantothenic Acid and Coenzyme A.Adenylating enzymes in Mycobacterium tuberculosis as drug targets.Protein targets for structure-based anti-Mycobacterium tuberculosis drug discovery.Structure-guided design of thiazolidine derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors.Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy.Automating crystallographic structure solution and refinement of protein-ligand complexes.Homology modelling of protein-protein complexes: a simple method and its possibilities and limitations.A detailed biochemical characterization of phosphopantothenate synthetase, a novel enzyme involved in coenzyme A biosynthesis in the Archaea.A comparison of the dynamics of pantothenate synthetase from M. tuberculosis and E. coli: computational studies.Precise Probing of Residue Roles by Post-Translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites.Confirmation of a Protein-Protein Interaction in the Pantothenate Biosynthetic Pathway by Using Sortase-Mediated Labelling.Alanine mutation of the catalytic sites of Pantothenate Synthetase causes distinct conformational changes in the ATP binding region.Molecular adaptation and allostery in plant pantothenate synthetases.Synthesis and evaluation of antimicrobial, antitubercular and anticancer activities of 2-(1-benzoyl-1H-benzo[d]imidazol-2-ylthio)-N-substituted acetamides.Binding of pyrazole-based inhibitors to Mycobacterium tuberculosis pantothenate synthetase: docking and MM-GB(PB)SA analysisSalicylanilide diethyl phosphates as potential inhibitors of some mycobacterial enzymes
P2860
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P2860
Crystal structures of a pantothenate synthetase fromM. tuberculosisand its complexes with substrates and a reaction intermediate
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Crystal structures of a pantot ...... es and a reaction intermediate
@ast
Crystal structures of a pantot ...... es and a reaction intermediate
@en
Crystal structures of a pantot ...... es and a reaction intermediate
@nl
type
label
Crystal structures of a pantot ...... es and a reaction intermediate
@ast
Crystal structures of a pantot ...... es and a reaction intermediate
@en
Crystal structures of a pantot ...... es and a reaction intermediate
@nl
prefLabel
Crystal structures of a pantot ...... es and a reaction intermediate
@ast
Crystal structures of a pantot ...... es and a reaction intermediate
@en
Crystal structures of a pantot ...... es and a reaction intermediate
@nl
P2860
P356
P1433
P1476
Crystal structures of a pantot ...... es and a reaction intermediate
@en
P2093
Shuishu Wang
P2860
P304
P356
10.1110/PS.0241803
P577
2003-05-01T00:00:00Z