Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development
about
A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of ChloroquineGlutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular trapsCatalytic cycle of human glutathione reductase near 1 A resolutionInteractions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparumSafety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841]Expression and biochemical characterization of the Plasmodium falciparum DNA repair enzyme, flap endonuclease-1 (PfFEN-1)The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsMechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductaseA structural annotation resource for the selection of putative target proteins in the malaria parasite.A comparative proteomic analysis of the simple amino acid repeat distributions in Plasmodia reveals lineage specific amino acid selection.Reactions of antimalarial peroxides with each of leucomethylene blue and dihydroflavins: flavin reductase and the cofactor model exemplified.The crystal structure of dynein intermediate chain-light chain roadblock complex gives new insights into dynein assemblyCrystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism.Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquitoTLS from fundamentals to practice.Methylene blue as an antimalarial agent.Plasmodium falciparum thioredoxins and glutaredoxins as central players in redox metabolism.Degrees of chloroquine resistance in Plasmodium - is the redox system involved?Structure of the Human Factor VIII C2 Domain in Complex with the 3E6 Inhibitory Antibody.In silico target fishing and pharmacological profiling for the isoquinoline alkaloids of Macleaya cordata (Bo Luo Hui)1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agentsLow Complexity Regions behave as tRNA sponges to help co-translational folding of plasmodial proteins.Role and Regulation of Glutathione Metabolism in Plasmodium falciparum.Diagnosis of red cell G6PD deficiency in rural Burkina Faso: comparison of a rapid fluorescent enzyme test on filter paper with polymerase chain reaction based genotyping.Identification of a thioredoxin reductase from Babesia microti during mammalian infection.Synthesis and redox-enzyme modulation by amino-1,4-dihydro-benzo[d][1,2]dithiine derivatives.Molecular genetics evidence for the in vivo roles of the two major NADPH-dependent disulfide reductases in the malaria parasite.Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action.The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine.Haemolysis risk in methylene blue treatment of G6PD-sufficient and G6PD-deficient West-African children with uncomplicated falciparum malaria: a synopsis of four RCTs.Thioredoxin reductase from the malaria mosquito Anopheles gambiae.Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Asexual and Transmissible Malaria Parasites.Glutathione reductase activity with an oxidized methylated glutathione analog.Efficacy and safety of methylene blue in the treatment of malaria: a systematic review.Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages
P2860
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P2860
Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Glutathione reductase of the m ...... ture and inhibitor development
@ast
Glutathione reductase of the m ...... ture and inhibitor development
@en
Glutathione reductase of the m ...... ture and inhibitor development
@nl
type
label
Glutathione reductase of the m ...... ture and inhibitor development
@ast
Glutathione reductase of the m ...... ture and inhibitor development
@en
Glutathione reductase of the m ...... ture and inhibitor development
@nl
prefLabel
Glutathione reductase of the m ...... ture and inhibitor development
@ast
Glutathione reductase of the m ...... ture and inhibitor development
@en
Glutathione reductase of the m ...... ture and inhibitor development
@nl
P2093
P921
P1476
Glutathione reductase of the m ...... ture and inhibitor development
@en
P2093
M Schirmer
R H Schirmer
S N Savvides
P304
P356
10.1016/S0022-2836(03)00347-4
P407
P50
P577
2003-05-01T00:00:00Z