Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
about
Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologueModulation of human nuclear receptor LRH-1 activity by phospholipids and SHPIdentification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptorInsights into Orphan Nuclear Receptors as Prognostic Markers and Novel Therapeutic Targets for Breast CancerPhospholipid--driven gene regulationStructure of SF-1 Bound by Different Phospholipids: Evidence for Regulatory LigandsThe structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1Crystal Structure of Fushi Tarazu Factor 1 Ligand Binding Domain/Fushi Tarazu Peptide Complex Identifies New Class of Nuclear ReceptorsStructural basis of coactivation of liver receptor homolog-1 by -cateninDivergent Sequence Tunes Ligand Sensitivity in Phospholipid-regulated Hormone ReceptorsAntidiabetic phospholipid–nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulationVestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone ReceptorcAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoterThe nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesisTIPE3 is the transfer protein of lipid second messengers that promote cancerLiver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammationLRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner.Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity.Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner.Nuclear receptors: the evolution of diversity.Minireview: Tipping the balance: ligand-independent activation of steroid receptors.The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification.The LIM domain protein FHL2 interacts with the NR5A family of nuclear receptors and CREB to activate the inhibin-α subunit gene in ovarian granulosa cells.Structural and functional insights into nuclear receptor signaling.Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting.Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programsThe Drosophila FTZ-F1 nuclear receptor mediates juvenile hormone activation of E75A gene expression through an intracellular pathway.Aromatase, breast cancer and obesity: a complex interaction.Liver receptor homolog-1 (LRH-1): a potential therapeutic target for cancerStructure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket.Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene.Emerging actions of the nuclear receptor LRH-1 in the gut.Accurate prediction of the bound form of the Akt pleckstrin homology domain using normal mode analysis to explore structural flexibilityUnderstanding nuclear receptor form and function using structural biologyOrphan nuclear receptors as targets for drug development.
P2860
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P2860
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
@ast
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
@en
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
@nl
type
label
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
@ast
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
@en
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
@nl
prefLabel
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
@ast
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
@en
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
@nl
P2093
P1433
P1476
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
@en
P2093
Elena P Sablin
Holly A Ingraham
Irina N Krylova
Robert J Fletterick
P304
P356
10.1016/S1097-2765(03)00236-3
P577
2003-06-01T00:00:00Z