Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis - Wikidata - wikimedia - TriplyDB

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

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Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures.Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation Mechanism of action and inhibition of dehydrosqualene synthase Human isoprenoid synthase enzymes as therapeutic targets X-ray Crystal Structure of Aristolochene Synthase from Aspergillus terreus and Evolution of Templates for the Cyclization of Farnesyl Diphosphate † , ‡Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation †Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation Crystal Structure of (+)-δ-Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer Crystal Structure of Heterodimeric Hexaprenyl Diphosphate Synthase from Micrococcus luteus B-P 26 Reveals That the Small Subunit Is Directly Involved in the Product Chain Length Regulation Structure and Mechanism of an Arabidopsis Medium/Long-Chain-Length Prenyl Pyrophosphate Synthase O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily Mechanistic Insights from the Binding of Substrate and Carbocation Intermediate Analogues to Aristolochene Synthase Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase Structural Insights into Ubiquinone Biosynthesis in Membranes Crystal structures of ligand-bound octaprenyl pyrophosphate synthase fromEscherichia colireveal the catalytic and chain-length determining mechanisms Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site Structure of a membrane-embedded prenyltransferase homologous to UBIAD1 The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis Manual classification strategies in the ECOD database.Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5.Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control.Methods for Structural and Functional Analyses of Intramembrane Prenyltransferases in the UbiA Superfamily.Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy.Adaptive evolution of the chrysanthemyl diphosphate synthase gene involved in irregular monoterpene metabolism.The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.Unearthing the roots of the terpenome Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries Functional analysis of (4S)-limonene synthase mutants reveals determinants of catalytic outcome in a model monoterpene synthase.Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implications Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa.Terpene Specialized Metabolism in Arabidopsis thaliana 2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.Terpenoid synthase structures: a so far incomplete view of complex catalysis.1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase

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P2860

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

http://www.wikidata.org/entity/Q27642782

description

2004 nî lūn-bûn

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2004 թուականի Մարտին հրատարակուած գիտական յօդուած

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2004 թվականի մարտին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

@ast

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

@en

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

@nl

type

label

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

@ast

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

@en

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

@nl

prefLabel

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

@ast

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

@en

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

@nl

P1433

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P1433

Journal of Biological Chemistry

P1476

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

@en

P2093

Alexei Broun

http://www.w3.org/2001/XMLSchema#string

David J Hosfield

http://www.w3.org/2001/XMLSchema#string

Douglas R Dougan

http://www.w3.org/2001/XMLSchema#string

John Finn

http://www.w3.org/2001/XMLSchema#string

Leslie W Tari

http://www.w3.org/2001/XMLSchema#string

Yanming Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Processing of X-ray diffraction data collected in oscillation mode

Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution

Regulation of product chain length by isoprenyl diphosphate synthases

XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

Promising therapeutic targets for antileishmanial drugs.

The pleiotropic effects of HMG-CoA reductase inhibitors: their role in osteoporosis and dementia.

Antitumor effects of bisphosphonates.

A fully integrated protein crystallization platform for small-molecule drug discovery.

Bisphosphonate treatment of osteoporosis.

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8526-8529

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scholarly article

P356

10.1074/JBC.C300511200

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P407

P433

10

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P478

279

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Ronald V Swanson

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2003-12-12T00:00:00Z

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P698

14672944

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