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Identification of small molecule inhibitors of anthrax lethal factor

Identification of small molecule inhibitors of anthrax lethal factor

http://www.wikidata.org/entity/Q27642936

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Metalloproteinase inhibitors, nonantimicrobial chemically modified tetracyclines, and ilomastat block Bacillus anthracis lethal factor activity in viable cells Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor Ligand-bound Structures Provide Atomic Snapshots for the Catalytic Mechanism of D-Amino Acid Deacylase Lethal and edema toxins in the pathogenesis of Bacillus anthracis septic shock: implications for therapy Engineered single-domain antibodies with high protease resistance and thermal stability Importance of explicit smeared lone-pairs in anisotropic polarizable molecular mechanics. Torture track angular tests for exchange-repulsion and charge transfer contributions.Novel Benzimidazole Inhibitors of Botulinum Neurotoxin/A Display Enzyme and Cell-Based Potency.Identification of novel non-hydroxamate anthrax toxin lethal factor inhibitors by topomeric searching, docking and scoring, and in vitro screening.Cationic polyamines inhibit anthrax lethal factor protease Polyvalent inhibitors of anthrax toxin that target host receptors Inhibitors of bacterial virulence identified in a surrogate host model.High-affinity, human antibody-like antibody fragment (single-chain variable fragment) neutralizing the lethal factor (LF) of Bacillus anthracis by inhibiting protective antigen-LF complex formation.Chelator fragment libraries for targeting metalloproteinases.Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection).Identification of Small Molecule Inhibitors of Clostridium perfringens ε-Toxin Cytotoxicity Using a Cell-Based High-Throughput Screen Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors.A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis.Novel strategies to combat bacterial virulence.Efficient synthetic inhibitors of anthrax lethal factor.Protection from anthrax toxin-mediated killing of macrophages by the combined effects of furin inhibitors and chloroquine.Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors.Passive protection against anthrax by using a high-affinity antitoxin antibody fragment lacking an Fc region Development of a comprehensive, validated pharmacophore hypothesis for anthrax toxin lethal factor (LF) inhibitors using genetic algorithms, Pareto scoring, and structural biology.Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening Novel imidazoline antimicrobial scaffold that inhibits DNA replication with activity against mycobacteria and drug resistant Gram-positive cocci Detection of anthrax toxin in the serum of animals infected with Bacillus anthracis by using engineered immunoassays Designing inhibitors of anthrax toxin Identification of toxin inhibitors using a magnetic nanosensor-based assay.Virstatin inhibits dimerization of the transcriptional activator ToxT Highly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors.Antitoxins: novel strategies to target agents of bioterrorism.Inhibitors of the Metalloproteinase Anthrax Lethal Factor.Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting.Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group The evolving field of biodefence: therapeutic developments and diagnostics.Statistical analysis, optimization, and prioritization of virtual screening parameters for zinc enzymes including the anthrax toxin lethal factor.

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P2860

Identification of small molecule inhibitors of anthrax lethal factor

http://www.wikidata.org/entity/Q27642936

description

2004 nî lūn-bûn

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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հունվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Identification of small molecule inhibitors of anthrax lethal factor

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Identification of small molecule inhibitors of anthrax lethal factor

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Identification of small molecule inhibitors of anthrax lethal factor

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type

label

Identification of small molecule inhibitors of anthrax lethal factor

@ast

Identification of small molecule inhibitors of anthrax lethal factor

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Identification of small molecule inhibitors of anthrax lethal factor

@nl

prefLabel

Identification of small molecule inhibitors of anthrax lethal factor

@ast

Identification of small molecule inhibitors of anthrax lethal factor

@en

Identification of small molecule inhibitors of anthrax lethal factor

@nl

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Nature Structural & Molecular Biology

P1476

Identification of small molecule inhibitors of anthrax lethal factor

@en

P2093

Ann R Hermone

http://www.w3.org/2001/XMLSchema#string

Benjamin E Turk

http://www.w3.org/2001/XMLSchema#string

Connor McGrath

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Daniel W Zaharevitz

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Douglas Lane

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Edward A Sausville

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James Burnett

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James Schmidt

http://www.w3.org/2001/XMLSchema#string

M Javad Aman

http://www.w3.org/2001/XMLSchema#string

Rick Gussio

http://www.w3.org/2001/XMLSchema#string

P2860

Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density

Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor

Density-functional thermochemistry. III. The role of exact exchange

Improved methods for building protein models in electron density maps and the location of errors in these models

Accurate spin-dependent electron liquid correlation energies for local spin density calculations: a critical analysis

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Processing of X-ray diffraction data collected in oscillation mode

Crystal structure of the anthrax lethal factor

The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor

The CCP4 suite: programs for protein crystallography

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67-72

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scholarly article

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3138519

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10.1038/NSMB711

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1

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11

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Robert Schwarzenbacher

Lewis C. Cantley

Rekha G Panchal

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2004-01-01T00:00:00Z

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1009079835

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14718925

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