Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
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Obstructing toxin pathways by targeted pore blockageCrystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron InteractionGlycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype FGangliosides as High Affinity Receptors for Tetanus NeurotoxinA Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic α-Exosite Binding RegionCrystal Structure of the Botulinum Neurotoxin Type G Binding Domain: Insight into Cell Surface BindingStructural Analysis of Botulinum Neurotoxin Type G Receptor Binding,Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent mannerIdentification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA,Structural analysis of the receptor binding domain of botulinum neurotoxin serotype DCrystal structure of the functional region of Uro-adherence factor A from Staphylococcus saprophyticus reveals participation of the B domain in ligand bindingThe biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sitesBotulinum Neurotoxin Serotype C Associates with Dual Ganglioside Receptors to Facilitate Cell EntryBotulinum Neurotoxin Is Shielded by NTNHA in an Interlocked ComplexStructure of dual receptor binding to botulinum neurotoxin BCrystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and IIProfile of Axel BrungerHuman synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicityIdentification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin AInduced folding in RNA recognition by Arabidopsis thaliana DCL1Molecular assembly of botulinum neurotoxin progenitor complexes.Insights into the evolutionary origins of clostridial neurotoxins from analysis of the Clostridium botulinum strain A neurotoxin gene clusterBotulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins.Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors.Tetanus neurotoxin utilizes two sequential membrane interactions for channel formation.What next for botulism vaccine development?Potent neutralization of botulinum neurotoxin/B by synergistic action of antibodies recognizing protein and ganglioside receptor binding domain.Tetanus toxin entry. Nidogens are therapeutic targets for the prevention of tetanus.Identification of fibroblast growth factor receptor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT/A).The C-terminal heavy-chain domain of botulinum neurotoxin a is not the only site that binds neurons, as the N-terminal heavy-chain domain also plays a very active role in toxin-cell binding and interactions.Unique ganglioside binding by botulinum neurotoxins C and D-SAIdentification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.Post-translational modifications and lipid binding profile of insect cell-expressed full-length mammalian synaptotagmin 1Diverse binding modes, same goal: The receptor recognition mechanism of botulinum neurotoxin.Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly.Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum Neurotoxin Serotype/A Inhibit Catalytic ActivityEpitope characterization of sero-specific monoclonal antibody to Clostridium botulinum neurotoxin type AArchitecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery.Production and evaluation of a recombinant subunit vaccine against botulinum neurotoxin serotype B using a 293E expression system.Heat-Labile Enterotoxin IIa, a Platform To Deliver Heterologous Proteins into Neurons.
P2860
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P2860
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
@ast
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
@en
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
@nl
type
label
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
@ast
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
@en
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
@nl
prefLabel
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
@ast
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
@en
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
@nl
P50
P3181
P356
P1433
P1476
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
@en
P2093
Thomas Binz
P2888
P304
P3181
P356
10.1038/NATURE05387
P407
P577
2006-12-21T00:00:00Z
P6179
1010841506