Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor
about
The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cellsT-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen TargetingMinimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimersNarrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restriction Can Explain Disease Susceptibility of B4 ChickensT-cell Receptor Specificity Maintained by Altered ThermodynamicsMolecular Basis of a Dominant T Cell Response to an HIV Reverse Transcriptase 8-mer Epitope Presented by the Protective Allele HLA-B*51:01Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability.Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.Cellular-level versus receptor-level response threshold hierarchies in T-cell activation.The molecular determinants of CD8 co-receptor function.Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers.Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.Rhesus macaque: a tight homodimeric CD8alphaalpha.Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.
P2860
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P2860
Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Computational design and cryst ...... uman CD8 alphaalpha coreceptor
@ast
Computational design and cryst ...... uman CD8 alphaalpha coreceptor
@en
Computational design and cryst ...... uman CD8 alphaalpha coreceptor
@nl
type
label
Computational design and cryst ...... uman CD8 alphaalpha coreceptor
@ast
Computational design and cryst ...... uman CD8 alphaalpha coreceptor
@en
Computational design and cryst ...... uman CD8 alphaalpha coreceptor
@nl
prefLabel
Computational design and cryst ...... uman CD8 alphaalpha coreceptor
@ast
Computational design and cryst ...... uman CD8 alphaalpha coreceptor
@en
Computational design and cryst ...... uman CD8 alphaalpha coreceptor
@nl
P2093
P356
P1433
P1476
Computational design and cryst ...... uman CD8 alphaalpha coreceptor
@en
P2093
Anne-lise Vuidepot
Bent K Jakobsen
John I Bell
Jonathan M Boulter
Malkit Sami
Meir Glick
Pierre J Rizkallah
P2860
P356
10.1002/PROT.21176
P407
P577
2007-04-01T00:00:00Z