Structural determinants of the enantioselectivity of the hydroxynitrile lyase from Hevea brasiliensis

Structural determinants of the enantioselectivity of the hydroxynitrile lyase from Hevea brasiliensis

Item
http://www.wikidata.org/entity/Q27643643
Atomic resolution crystal structures and quantum chemistry meet to reveal subtleties of hydroxynitrile lyase catalysisHydroxynitrile Lyases with α/β-Hydrolase Fold: Two Enzymes with Almost Identical 3D Structures but Opposite Enantioselectivities and Different Reaction MechanismsIncreasing the reaction rate of hydroxynitrile lyase from Hevea brasiliensis toward mandelonitrile by copying active site residues from an esterase that accepts aromatic esters.Comparative Bioinformatic Analysis of Active Site Structures in Evolutionarily Remote Homologues of α,β-Hydrolase Superfamily EnzymesUncovering divergent evolution of α/β-hydrolases: a surprising residue substitution needed to convert Hevea brasiliensis hydroxynitrile lyase into an esteraseUnveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom.An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an alpha/beta-hydrolase fold.Controlling enantioselectivity of esterase in asymmetric hydrolysis of aryl prochiral diesters by introducing aromatic interactions.Identical active sites in hydroxynitrile lyases show opposite enantioselectivity and reveal possible ancestral mechanism.
P2860

Structural determinants of the enantioselectivity of the hydroxynitrile lyase from Hevea brasiliensis

Item
http://www.wikidata.org/entity/Q27643643
description
2007 nî lūn-bûn
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2007 թուականի Մարտին հրատարակուած գիտական յօդուած
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2007 թվականի մարտին հրատարակված գիտական հոդված
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2007年の論文
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Structural determinants of the ...... lyase from Hevea brasiliensis
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Structural determinants of the ...... lyase from Hevea brasiliensis
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Structural determinants of the ...... lyase from Hevea brasiliensis
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Structural determinants of the ...... lyase from Hevea brasiliensis
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Structural determinants of the ...... lyase from Hevea brasiliensis
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10.1016/J.JBIOTEC.2006.12.009
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