Hydroxynitrile Lyases with α/β-Hydrolase Fold: Two Enzymes with Almost Identical 3D Structures but Opposite Enantioselectivities and Different Reaction Mechanisms
about
Biochemical and structural characterization of a novel bacterial manganese-dependent hydroxynitrile lyaseHow the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes.Increasing the reaction rate of hydroxynitrile lyase from Hevea brasiliensis toward mandelonitrile by copying active site residues from an esterase that accepts aromatic esters.Evolution of a Catalytic Mechanism.Immobilisation of hydroxynitrile lyases.Xylella fastidiosa esterase rather than hydroxynitrile lyase.A QM/MM study of the reaction mechanism of (R)-hydroxynitrile lyases from Arabidopsis thaliana (AtHNL).Identical active sites in hydroxynitrile lyases show opposite enantioselectivity and reveal possible ancestral mechanism.
P2860
Q27685416-B9071519-47A6-4374-94E3-74A7562DB298Q33756522-8BCD09CE-B706-4254-830E-DBB72376AA5EQ34206304-5794FF00-5C2C-4F4D-BCDC-3DEB8498FF9AQ37237749-EC39B371-0FC7-48A8-B746-54ADCC6080ACQ38077680-F0BFFCBF-1108-4036-A9BA-88F384EAAA92Q41432898-444A3303-9186-4D5A-B64E-3BDB64518F01Q53032524-FD0CE928-83DD-42E1-B8F7-7E5C1AB54ACEQ53116443-075E4C92-45C6-474D-BB1D-BDE50968C889
P2860
Hydroxynitrile Lyases with α/β-Hydrolase Fold: Two Enzymes with Almost Identical 3D Structures but Opposite Enantioselectivities and Different Reaction Mechanisms
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Hydroxynitrile Lyases with α/β ...... Different Reaction Mechanisms
@ast
Hydroxynitrile Lyases with α/β ...... Different Reaction Mechanisms
@en
Hydroxynitrile Lyases with α/β ...... Different Reaction Mechanisms
@nl
type
label
Hydroxynitrile Lyases with α/β ...... Different Reaction Mechanisms
@ast
Hydroxynitrile Lyases with α/β ...... Different Reaction Mechanisms
@en
Hydroxynitrile Lyases with α/β ...... Different Reaction Mechanisms
@nl
prefLabel
Hydroxynitrile Lyases with α/β ...... Different Reaction Mechanisms
@ast
Hydroxynitrile Lyases with α/β ...... Different Reaction Mechanisms
@en
Hydroxynitrile Lyases with α/β ...... Different Reaction Mechanisms
@nl
P2093
P2860
P356
P1433
P1476
Hydroxynitrile Lyases with α/β ...... Different Reaction Mechanisms
@en
P2093
Christoph Kratky
Jennifer N Andexer
Nicole Staunig
Thorsten Eggert
P2860
P304
P356
10.1002/CBIC.201200239
P577
2012-09-03T00:00:00Z